MirGeneDB 3.0
MirGeneDB ID

Cin-Let-7-P2o1-v2

Family name LET-7 (all species)
Seed UGAGGUA
Species Sea Squirt (Ciona intestinalis)
MiRBase ID cin-let-7a-1
Paralogues Cin-Let-7-P1  Cin-Let-7-P2o1-v1  Cin-Let-7-P2o2  Cin-Let-7-P2o3  Cin-Let-7-P2o4  Cin-Let-7-P2o5 
Orthologues Aae-Let-7  Aga-Let-7  Agr-Let-7  Bge-Let-7  Bko-Let-7  Bpl-Let-7  Cte-Let-7  Dan-Let-7  Dlo-Let-7  Dma-Let-7  Dme-Let-7  Dmo-Let-7  Dpu-Let-7  Dsi-Let-7  Dya-Let-7  Eba-Let-7  Egr-Let-7  Esc-Let-7  Gpa-Let-7  Gsa-Let-7  Gsp-Let-7  Hme-Let-7  Hmi-Let-7  Hru-Let-7  Isc-Let-7  Lan-Let-7  Lgi-Let-7  Lhy-Let-7  Llo-Let-7  Mgi-Let-7  Mom-Let-7  Npo-Let-7  Obi-Let-7  Ofu-Let-7  Ovu-Let-7  Pau-Let-7  Pca-Let-7  Pcr-Let-7  Pdu-Let-7  Pfl-Let-7  Ple-Let-7  Pmi-Let-7  Pve-Let-7  Rph-Let-7  Sko-Let-7  Sma-Let-7  Sne-Let-7  Snu-Let-7  Spu-Let-7  Sro-Let-7  Tca-Let-7  Tur-Let-7  War-Let-7  Xbo-Let-7 
Node of Origin (locus) C. intestinalis
Node of Origin (family) Bilateria
Genome context
(ci3)		 4: 2157421-2157502 [+] UCSC Ensembl
Clustered miRNAs
(< 50kb from Let-7-P2o1-v2)		 Let-7-P2o1-v2 4: 2157421-2157502 [+] UCSC Ensembl
Let-7-P2o1-v1 4: 2157422-2157502 [+] UCSC Ensembl
Let-7-P2o2 4: 2157552-2157624 [+] UCSC Ensembl
Let-7-P2o3 4: 2157948-2158018 [+] UCSC Ensembl
Let-7-P2o4 4: 2158141-2158206 [+] UCSC Ensembl
Let-7-P2o5 4: 2158340-2158414 [+] UCSC Ensembl
Precursor
(pre-Mir +30nt flank)
GACCACCGAAACAACAUGGCCGUGACCACAAUGAGGUAGUAGGUUAUGCAGUUAUAGCCUCCCUUUUAUACUGAGUGGAGCACAGGAGAUACUGUGUAACCUUCUGCCUUUGUGGCUUCGUGUUUCUAUCAUCAGCUCCCAC
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Structure
        10         20         30        40        50        60        70 
GACCACCGAAACAACAU-   -| UGA     AU       U            UAUAGCCUCCCUUUUAUA 
                  GGC CG   CCACA  GAGGUAG AGGUUAUGCAGU                  C
                  UUG GC   GGUGU  UUCCGUC UCCAAUGUGUCA                  U
CACCCUCGACUACUAUCU   U^ UUC     --       U            UAGAGGACACGAGGUGAG 
140       130       120         110       100        90        80
Deep sequencing
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CommentThis paralogue is related to the vertebrate P2s but it is not yet possible to disentangle the phylogenetic history of vertebrate Let-7 P2s and thus the ascidian genes are classified as orphans pending further data. There is also a second Dicer cut -1 on the 3p arm.
3' NTU Yes
MotifsUG at 5p(-14), CNNC at 3p(+17)
Tissue expression
-   +
C- C- C- C- C- C- C- C- C- C- Ga La La
Mature sequence

Cin-Let-7-P2o1-v2_5p
mirBase accessionMIMAT0006086
Sequence 
0- AUGAGGUAGUAGGUUAUGCAGU -22
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Star sequence

Cin-Let-7-P2o1-v2_3p*
mirBase accessionMIMAT0015247
Sequence 
62- UGUGUAACCUUCUGCCUUUG -82
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