MirGeneDB 3.0

MirGeneDB ID

Sma-Mir-2-o131

Family name MIR-2 (all species)
Seed AUCACAG
Species Blood fluke (Schistosoma mansoni)
MiRBase ID sma-mir-2b
Paralogues Sma-Mir-2-o130  Sma-Mir-2-o132  Sma-Mir-2-o133  Sma-Mir-2-o134  Sma-Mir-2-o135 
Orthologues Gsp-Mir-2  Ple-Mir-2 
Node of Origin (locus) S. mansoni
Node of Origin (family) Protostomia
Genome context
(GCA_000237925.5_SM_V9_genomic)
OU426849.1: 4544155-4544212 [+] UCSC Ensembl
Clustered miRNAs
(< 50kb from Mir-2-o131)
Mir-71-o5 OU426849.1: 4543971-4544024 [+] UCSC Ensembl
Mir-2-o130 OU426849.1: 4544063-4544117 [+] UCSC Ensembl
Mir-2-o131 OU426849.1: 4544155-4544212 [+] UCSC Ensembl
Mir-2-o132 OU426849.1: 4544251-4544316 [+] UCSC Ensembl
Precursor
(pre-Mir +30nt flank)
AGGCGCACGUCCACCACUGCAGGUGGUGCGCGUCUCAAGGGACUGUGAAACAUCGUAACCAUUUGUAUCACAGCCCUGCUUGGGACACAGCCUACCUGCUAAGACAUCUCUUUGUCCC
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Structure
        10         20        30            40        50        
AGGCGCACGUCCACCACU-        U  GC-      ---|   A      A   UCGUA 
                   GCAGGUGG GC   GUCUCA   AGGG CUGUGA ACA     \
                   CGUCCAUC CG   CAGGGU   UCCC GACACU UGU     A
CCCUGUUUCUCUACAGAAU        -  ACA      UCG^   -      A   UUACC 
      110       100         90        80         70        60
Deep sequencing
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CommentIt is not clear either from phylogenetic or syntenic information how many Mir-2 genes were present in the last common ancestor of protostomes and how the multiple paralogues in lophotrochozoans relate to the four Mir-2 genes in arthropods. Thus all lophotrochozoan genes aside from Mir-2-P12 are classified as orphans pending further data and analysis.
3' NTU No
MotifsCNNC at 3p(+17)
Tissue expression
 +
Ad Ad Ad Ad Ad Ad Ad Ad Ad Ad Ad Ad Ad Ad Ad Ce Ce Ce Eg Eg Eg Eg Eg Eg Mi Mi Sc Sc Sc Sm Sm Sp Sp Sp
Star sequence

Sma-Mir-2-o131_5p*

mirBase accessionMIMAT0025031
Sequence
0- CGUCUCAAGGGACUGUGAAACA -22
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Mature sequence

Sma-Mir-2-o131_3p

mirBase accessionMIMAT0025032
Sequence
35- UAUCACAGCCCUGCUUGGGACAC -58
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