Mir-2-o132

MirGeneDB ID

Sma-Mir-2-o132

Family name

MIR-2 (all species)

Seed

AUCACAG

Species

Blood fluke (Schistosoma mansoni)

MiRBase ID

sma-mir-2e

Paralogues

Sma-Mir-2-o130 Sma-Mir-2-o131 Sma-Mir-2-o133 Sma-Mir-2-o134 Sma-Mir-2-o135

Orthologues

Gsp-Mir-2 Ple-Mir-2

Node of Origin (locus)

S. mansoni

Node of Origin (family)

Protostomia

Genome context
(GCA_000237925.5_SM_V9_genomic)

OU426849.1: 4544251-4544316 [+] UCSC Ensembl

Clustered miRNAs
(< 50kb from Mir-2-o132)

Mir-71-o5 OU426849.1: 4543971-4544024 [+] UCSC Ensembl
Mir-2-o130 OU426849.1: 4544063-4544117 [+] UCSC Ensembl
Mir-2-o131 OU426849.1: 4544155-4544212 [+] UCSC Ensembl
Mir-2-o132 OU426849.1: 4544251-4544316 [+] UCSC Ensembl

Precursor
(pre-Mir +30nt flank)

UGCUAAGACAUCUCUUUGUCCCAUCGCUCUUACCAACUUUGACUGAGUUAUACUGCUUUUGUAAGCCUUGUAUAUCACAGUCCAAGCUUUGGUAAGUUUUGGUGGGUUGAUCGACAGCUGGUUUUC

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Structure

        10         20         30          40        50        60 
UGCUAAGACAUCUCUUUGU-       CU-        --|  U     AGU    CUGCUUUU 
                    CCCAUCG   CUUACCAA  CUU GACUG   UAUA        G
                    GGGUGGU   GAAUGGUU  GAA CUGAC   AUAU        U
CUUUUGGUCGACAGCUAGUU       UUU        UC^  C     ACU    GUUCCGAA 
    120       110       100        90        80        70

Deep sequencing

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Comment

It is not clear either from phylogenetic or syntenic information how many Mir-2 genes were present in the last common ancestor of protostomes and how the multiple paralogues in lophotrochozoans relate to the four Mir-2 genes in arthropods. Thus all lophotrochozoan genes aside from Mir-2-P12 are classified as orphans pending further data and analysis.

3' NTU

Unknown

Motifs

UG at 5p(-14), CNNC at 3p(+17)

Tissue expression

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Star sequence

Sma-Mir-2-o132_5p*

mirBase accession

MIMAT0025036

Sequence

0- UACCAACUUUGACUGAGUUAUA -22

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Mature sequence

Sma-Mir-2-o132_3p

mirBase accession

MIMAT0025037

Sequence

42- UAUCACAGUCCAAGCUUUGGUAAG -66

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