MirGeneDB 3.0

MirGeneDB ID

Sma-Mir-2-o135

Family name MIR-2 (all species)
Seed AUCACAG
Species Blood fluke (Schistosoma mansoni)
MiRBase ID sma-mir-2d
Paralogues Sma-Mir-2-o130  Sma-Mir-2-o131  Sma-Mir-2-o132  Sma-Mir-2-o133  Sma-Mir-2-o134 
Orthologues Gsp-Mir-2  Ple-Mir-2 
Node of Origin (locus) S. mansoni
Node of Origin (family) Protostomia
Genome context
(GCA_000237925.5_SM_V9_genomic)
HE601628.3: 9680098-9680158 [+] UCSC Ensembl
Clustered miRNAs
(< 50kb from Mir-2-o135)
Mir-71-o6 HE601628.3: 9679749-9679802 [+] UCSC Ensembl
Mir-2-o133 HE601628.3: 9679871-9679943 [+] UCSC Ensembl
Mir-2-o134 HE601628.3: 9679986-9680055 [+] UCSC Ensembl
Mir-2-o135 HE601628.3: 9680098-9680158 [+] UCSC Ensembl
Precursor
(pre-Mir +30nt flank)
UUAACCUUCGCAAACCAGGUUGUUGGCGCAUCCCUUGUUCGACUGUGAUGUGUUCGAAGUAAACUCAUAUCACAGCCGUGCUUAAGGGCUUCGUCAAAACUCUGAACAACACAUGUGAUAU
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Structure
        10           20        30          40        50         
UUAACCUUCGCAAACCA---    G      CAU      UU--| A          UUCGAA 
                    GGUU UUGGCG   CCCUUG    CG CUGUGAUGUG      \
                    UCAA AACUGC   GGGAAU    GC GACACUAUAC      G
UAUAGUGUACACAACAAGUC    -      UUC      UCGU^ C          UCAAAU 
 .       110       100         90        80        70        60
Deep sequencing
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CommentIt is not clear either from phylogenetic or syntenic information how many Mir-2 genes were present in the last common ancestor of protostomes and how the multiple paralogues in lophotrochozoans relate to the four Mir-2 genes in arthropods. Thus all lophotrochozoan genes aside from Mir-2-P12 are classified as orphans pending further data and analysis.
3' NTU Unknown
MotifsCNNC at 3p(+17)
Tissue expression
 +
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Star sequence

Sma-Mir-2-o135_5p*

mirBase accessionMIMAT0032135
Sequence
0- UCCCUUGUUCGACUGUGAUGUG -22
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Mature sequence

Sma-Mir-2-o135_3p

mirBase accessionMIMAT0025035
Sequence
37- UAUCACAGCCGUGCUUAAGGGCUU -61
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