Mir-154-P30

MirGeneDB ID

Mmu-Mir-154-P30

Family name

MIR-154 (all species)

Seed

GGUUACC

Species

House mouse (Mus musculus)

MiRBase ID

mmu-mir-409

Paralogues

Mmu-Mir-154-P1 Mmu-Mir-154-P2-v1 Mmu-Mir-154-P2-v2 Mmu-Mir-154-P3-v1 Mmu-Mir-154-P3-v2 Mmu-Mir-154-P4 Mmu-Mir-154-P5 Mmu-Mir-154-P6a-v1 Mmu-Mir-154-P6a-v2 Mmu-Mir-154-P7 Mmu-Mir-154-P8-o1 Mmu-Mir-154-P9 Mmu-Mir-154-P10-v1 Mmu-Mir-154-P10-v2 Mmu-Mir-154-P11 Mmu-Mir-154-P12 Mmu-Mir-154-P15 Mmu-Mir-154-P17 Mmu-Mir-154-P18 Mmu-Mir-154-P19 Mmu-Mir-154-P24 Mmu-Mir-154-P25 Mmu-Mir-154-P26 Mmu-Mir-154-P28-v1 Mmu-Mir-154-P28-v2 Mmu-Mir-154-P29 Mmu-Mir-154-P31 Mmu-Mir-154-P32 Mmu-Mir-154-P33

Orthologues

Bta-Mir-154-P30 Cfa-Mir-154-P30 Cja-Mir-154-P30 Cpo-Mir-154-P30 Dno-Mir-154-P30 Eca-Mir-154-P30 Ete-Mir-154-P30 Hsa-Mir-154-P30 Laf-Mir-154-P30 Mml-Mir-154-P30 Mmr-Mir-154-P30 Ocu-Mir-154-P30 Pab-Mir-154-P30 Rno-Mir-154-P30

Node of Origin (locus)

Eutheria

Node of Origin (family)

Eutheria

Genome context
(mm10)

chr12: 109743172-109743225 [+] UCSC Ensembl

Clustered miRNAs
(< 50kb from Mir-154-P30)

Mir-154-P1 chr12: 109709065-109709122 [+] UCSC Ensembl
Mir-154-P2-v2 chr12: 109710189-109710246 [+] UCSC Ensembl
Mir-154-P2-v1 chr12: 109710190-109710245 [+] UCSC Ensembl
Mir-154-P3-v1 chr12: 109710643-109710697 [+] UCSC Ensembl
Mir-154-P3-v2 chr12: 109710644-109710696 [+] UCSC Ensembl
Mir-154-P4 chr12: 109711806-109711862 [+] UCSC Ensembl
Mir-154-P5 chr12: 109712361-109712416 [+] UCSC Ensembl
Mir-154-P6a-v1 chr12: 109712523-109712578 [+] UCSC Ensembl
Mir-154-P6a-v2 chr12: 109712523-109712578 [+] UCSC Ensembl
Mir-154-P7 chr12: 109712823-109712880 [+] UCSC Ensembl
Mir-154-P8-o1 chr12: 109713503-109713562 [+] UCSC Ensembl
Mir-154-P9 chr12: 109715334-109715389 [+] UCSC Ensembl
Mir-154-P10-v1 chr12: 109715715-109715771 [+] UCSC Ensembl
Mir-154-P10-v2 chr12: 109715716-109715770 [+] UCSC Ensembl
Mir-666 chr12: 109717103-109717163 [+] UCSC Ensembl
Mir-154-P11 chr12: 109717268-109717325 [+] UCSC Ensembl
Mir-154-P12 chr12: 109718757-109718816 [+] UCSC Ensembl
Mir-667 chr12: 109720020-109720083 [+] UCSC Ensembl
Mir-376-P2 chr12: 109722733-109722790 [+] UCSC Ensembl
Mir-376-P4 chr12: 109723471-109723528 [+] UCSC Ensembl
Mir-376-P5 chr12: 109723787-109723844 [+] UCSC Ensembl
Mir-154-P15 chr12: 109724322-109724384 [+] UCSC Ensembl
Mir-154-P17 chr12: 109726829-109726891 [+] UCSC Ensembl
Mir-154-P18 chr12: 109727346-109727403 [+] UCSC Ensembl
Mir-154-P19 chr12: 109728136-109728197 [+] UCSC Ensembl
Mir-544 chr12: 109729335-109729391 [+] UCSC Ensembl
Mir-154-P24 chr12: 109733781-109733838 [+] UCSC Ensembl
Mir-134 chr12: 109734145-109734205 [+] UCSC Ensembl
Mir-154-P25 chr12: 109734910-109734968 [+] UCSC Ensembl
Mir-154-P26 chr12: 109738438-109738495 [+] UCSC Ensembl
Mir-154-P28-v2 chr12: 109739132-109739187 [+] UCSC Ensembl
Mir-154-P28-v1 chr12: 109739133-109739186 [+] UCSC Ensembl
Mir-154-P29 chr12: 109740515-109740574 [+] UCSC Ensembl
Mir-541 chr12: 109742422-109742487 [+] UCSC Ensembl
Mir-154-P30 chr12: 109743172-109743225 [+] UCSC Ensembl
Mir-154-P31 chr12: 109743303-109743358 [+] UCSC Ensembl
Mir-154-P32 chr12: 109743431-109743486 [+] UCSC Ensembl
Mir-154-P33 chr12: 109743729-109743784 [+] UCSC Ensembl
Mir-3072 chr12: 109747893-109747949 [+] UCSC Ensembl

Precursor
(pre-Mir +30nt flank)

CAUCCGAGCCUCUCCGUGGUACUCGGAGAGAGGUUACCCGAGCAACUUUGCAUCUGGAGGACGAAUGUUGCUCGGUGAACCCCUUUUCGGUAUCAAAUCCCUCCAGGGAGGCCA

Get precursor sequence

Structure

        10           20        30        40         50      
CAUCCGAGCCUCUCCGU---|    U       A    AC         -    CAUCU 
                    GGUAC CGGAGAG GGUU  CCGAGCAAC UUUG     \
                    CUAUG GCUUUUC CCAA  GGCUCGUUG AAGC     G
ACCGGAGGGACCUCCCUAAA^    -       C    GU         U    AGGAG 
  110       100        90         80        70        60

Deep sequencing

Go to detailed chart

Comment

This gene was classified as a non-canonical miRNA in Fromm et al. (2015) given that the Dicer cut is consistently +4. However, the Drosha cut is +2 and reads are abrogated with the Drosha knock-out and hence it is accepted here.

3' NTU

Motifs

UG at 5p(-14), CNNC at 3p(+17)

Tissue expression

Br	Br	Ce	Ce	Em	Em	He	Ki	Li	Lu	Ov	Pa	Sk	Sp	Te

Mature sequence

Mmu-Mir-154-P30_5p

mirBase accession

MIMAT0004746

Sequence

0- AGGUUACCCGAGCAACUUUGCAU -23

Get sequence

Proposed targets

microrna.org: MIMAT0004746
TargetScanVert: mmu-miR-409-5p
miRDB: MIMAT0004746

Co-mature sequence

Mmu-Mir-154-P30_3p

mirBase accession

MIMAT0001090

Sequence

32- GAAUGUUGCUCGGUGAACCCCU -54

Get sequence

Proposed targets

microrna.org: MIMAT0001090
TargetScanVert: mmu-miR-409-3p
miRDB: MIMAT0001090