Mir-2-o122b

MirGeneDB ID

Sme-Mir-2-o122b

Family name

MIR-2 (all species)

Seed

AUCACAG

Species

Freshwater planarian (Schmidtea mediterranea)

MiRBase ID

sme-mir-2a-2

Paralogues

Sme-Mir-2-o122a Sme-Mir-2-o123 Sme-Mir-2-o124 Sme-Mir-2-o125 Sme-Mir-2-o126 Sme-Mir-2-o127 Sme-Mir-2-o128 Sme-Mir-2-o129

Orthologues

Gsp-Mir-2 Ple-Mir-2

Node of Origin (locus)

S. mediterranea

Node of Origin (family)

Protostomia

Genome context
(Sme_GCA_002600895.1_ASM260089v1_alt)

NNSW01000001_dd_Smes_g4_1: 13481745-13481799 [+] UCSC Ensembl

Clustered miRNAs
(< 50kb from Mir-2-o122b)

Mir-71-o1b NNSW01000001_dd_Smes_g4_1: 13481649-13481705 [+] UCSC Ensembl
Mir-2-o122b NNSW01000001_dd_Smes_g4_1: 13481745-13481799 [+] UCSC Ensembl

Precursor
(pre-Mir +30nt flank)

GAUGGUCAUCAUAAUUGUUCACUUAAUUGAGUUCUACGGUGUUGUGAUAUAAUGAUUAUUUAUAUCACAGCCCCGCUUGGAACGCUAAAAUAUGAAUGUUCAUCAUUAAUUACAU

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Structure

        10          20        30          40        50      
GAUGGUCAUCAUAAUUG--    CUUAAUUGA      --|  U           AUGA 
                   UUCA         GUUCUA  CGG GUUGUGAUAUA    \
                   AAGU         CAAGGU  GCC CGACACUAUAU    U
UACAUUAAUUACUACUUGU    AUAAAAUCG      UC^  C           UUAU 
   110       100        90        80        70        60

Deep sequencing

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Comment

It is not clear either from phylogenetic or syntenic information how many Mir-2 genes were present in the last common ancestor of protostomes and how the multiple paralogues in lophotrochozoans relate to the four Mir-2 genes in arthropods. Thus all lophotrochozoan genes aside from Mir-2-P12 are classified as orphans pending further data and analysis.

3' NTU

Motifs

CNNC at 3p(+17)

Tissue expression

Ag	Ag	Di	Gf	Ne	Ph	Se	Se	Se	Se	Se	Se	Se	Se	Se	Se	Se	Wh	Wh	Wh

Star sequence

Sme-Mir-2-o122b_5p*

mirBase accession

MIMAT0012093

Sequence

0- GUUCUACGGUGUUGUGAUAUA -21

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Mature sequence

Sme-Mir-2-o122b_3p

mirBase accession

MIMAT0003963

Sequence

32- UAUCACAGCCCCGCUUGGAACGC -55

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