MirGeneDB 3.0

MirGeneDB ID

Sme-Mir-2-o123

Family name MIR-2 (all species)
Seed CAUCAUU
Species Freshwater planarian (Schmidtea mediterranea)
MiRBase ID sme-mir-2d
Paralogues Sme-Mir-2-o122a  Sme-Mir-2-o122b  Sme-Mir-2-o124  Sme-Mir-2-o125  Sme-Mir-2-o126  Sme-Mir-2-o127  Sme-Mir-2-o128  Sme-Mir-2-o129 
Orthologues Gsp-Mir-2  Ple-Mir-2 
Node of Origin (locus) S. mediterranea
Node of Origin (family) Protostomia
Genome context
(Sme_GCA_002600895.1_ASM260089v1_alt)
NNSW01000131_dd_Smes_g4_131: 1191304-1191374 [+] UCSC Ensembl
Clustered miRNAs
(< 50kb from Mir-2-o123)
Mir-71-o2 NNSW01000131_dd_Smes_g4_131: 1191188-1191254 [+] UCSC Ensembl
Mir-2-o123 NNSW01000131_dd_Smes_g4_131: 1191304-1191374 [+] UCSC Ensembl
Mir-2-o124 NNSW01000131_dd_Smes_g4_131: 1191422-1191481 [+] UCSC Ensembl
Mir-2-o125 NNSW01000131_dd_Smes_g4_131: 1191539-1191598 [+] UCSC Ensembl
Precursor
(pre-Mir +30nt flank)
AGUUCACUAGUGACAUUUUGCCUCUUACGGACAUCAUUAUUUGACUGUCGAUAGAUAUUGGUAACAUUAUUUUGGUAGUAUCACAGCCAAAUUUGAUGUCCUAAAUAAGGUAGUCACCUUCAUUGAUUAUA
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Structure
        10         20          30        40        50        60      
AGUUCACUAGUGACAUU-      C--|  C        UU     A    C    GAUAUUGGUAAC 
                  UUGCCU   UUA GGACAUCA  AUUUG CUGU GAUA            \
                  GAUGGA   AAU CCUGUAGU  UAAAC GACA CUAU            A
AUAUUAGUUACUUCCACU      AUA^  -        U-     C    -    GAUGGUUUUAUU 
 .       120       110        100         90         80        70
Deep sequencing
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CommentIt is not clear either from phylogenetic or syntenic information how many Mir-2 genes were present in the last common ancestor of protostomes and how the multiple paralogues in lophotrochozoans relate to the four Mir-2 genes in arthropods. Thus all lophotrochozoan genes aside from Mir-2-P12 are classified as orphans pending further data and analysis.
3' NTU No
MotifsCNNC at 3p(+17)
Tissue expression
 +
Se Se Se Se Se Se Se Se Se Se Se Se Ne Wh Wh Wh
Mature sequence

Sme-Mir-2-o123_5p

mirBase accessionMIMAT0012095
Sequence
0- ACAUCAUUAUUUGACUGUCGAUA -23
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Star sequence

Sme-Mir-2-o123_3p*

mirBase accessionMIMAT0003968
Sequence
50- UCACAGCCAAAUUUGAUGUCC -71
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