MirGeneDB 3.0

MirGeneDB ID

Sme-Mir-2-o125

Family name MIR-2 (all species)
Seed AUCACAG
Species Freshwater planarian (Schmidtea mediterranea)
MiRBase ID sme-mir-13
Paralogues Sme-Mir-2-o122a  Sme-Mir-2-o122b  Sme-Mir-2-o123  Sme-Mir-2-o124  Sme-Mir-2-o126  Sme-Mir-2-o127  Sme-Mir-2-o128  Sme-Mir-2-o129 
Orthologues Gsp-Mir-2  Ple-Mir-2 
Node of Origin (locus) S. mediterranea
Node of Origin (family) Protostomia
Genome context
(Sme_GCA_002600895.1_ASM260089v1_alt)
NNSW01000131_dd_Smes_g4_131: 1191539-1191598 [+] UCSC Ensembl
Clustered miRNAs
(< 50kb from Mir-2-o125)
Mir-71-o2 NNSW01000131_dd_Smes_g4_131: 1191188-1191254 [+] UCSC Ensembl
Mir-2-o123 NNSW01000131_dd_Smes_g4_131: 1191304-1191374 [+] UCSC Ensembl
Mir-2-o124 NNSW01000131_dd_Smes_g4_131: 1191422-1191481 [+] UCSC Ensembl
Mir-2-o125 NNSW01000131_dd_Smes_g4_131: 1191539-1191598 [+] UCSC Ensembl
Precursor
(pre-Mir +30nt flank)
UCAAUUGUGUUUGGAAAGCAACAUAAUGGGAGCCUUUGGCGGCUGUGAUAUGAUAAUUAUAUACAUAUCACAGUCAUGCUAAAGAGCUUGUAAAUUGUUACUAAUCGUCUCUCGUGCUUC
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Structure
        10          20        30         40          50        
UCAAUUGUGUUUGGAAAGC--    UAA  G    -       --|           AUAAU 
                     AACA   UG GAGC CUUUGGC  GGCUGUGAUAUG     \
                     UUGU   AU UUCG GAAAUCG  CUGACACUAUAC     U
CUUCGUGCUCUCUGCUAAUCA    UAA  G    A       UA^           AUAUA 
.       110       100        90        80        70        60
Deep sequencing
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CommentIt is not clear either from phylogenetic or syntenic information how many Mir-2 genes were present in the last common ancestor of protostomes and how the multiple paralogues in lophotrochozoans relate to the four Mir-2 genes in arthropods. Thus all lophotrochozoan genes aside from Mir-2-P12 are classified as orphans pending further data and analysis.
3' NTU No
MotifsCNNC at 3p(+17)
Tissue expression
 +
Ag Ag Di Gf Ne Ph Se Se Se Se Se Se Se Se Se Se Se Wh Wh Wh
Star sequence

Sme-Mir-2-o125_5p*

mirBase accessionMIMAT0012101
Sequence
0- AGCCUUUGGCGGCUGUGAUAUG -22
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Mature sequence

Sme-Mir-2-o125_3p

mirBase accessionMIMAT0003976
Sequence
35- UAUCACAGUCAUGCUAAAGAGCUUG -60
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