Let-7-P2c2

MirGeneDB ID

Hsa-Let-7-P2c2

Family name

LET-7 (all species)

Seed

GAGGUAG

Species

Human (Homo sapiens)

MiRBase ID

hsa-let-7i

Paralogues

Hsa-Let-7-P1b Hsa-Let-7-P1c Hsa-Let-7-P1d Hsa-Let-7-P2a1 Hsa-Let-7-P2a2 Hsa-Let-7-P2a3 Hsa-Let-7-P2b1 Hsa-Let-7-P2b2 Hsa-Let-7-P2b3 Hsa-Let-7-P2c1 Hsa-Let-7-P2c3

Orthologues

Aae-Let-7 Aca-Let-7-P2c2 Aga-Let-7 Agr-Let-7 Ami-Let-7-P2c2 Bge-Let-7 Bko-Let-7 Bpl-Let-7 Bta-Let-7-P2c2 Cfa-Let-7-P2c2 Cja-Let-7-P2c2 Cli-Let-7-P2c2 Cmi-Let-7-P2c2 Cpi-Let-7-P2c2 Cpo-Let-7-P2c2 Cte-Let-7 Dan-Let-7 Dlo-Let-7 Dma-Let-7 Dme-Let-7 Dmo-Let-7 Dno-Let-7-P2c2 Dpu-Let-7 Dre-Let-7-P2c2b Dsi-Let-7 Dya-Let-7 Eba-Let-7 Eca-Let-7-P2c2 Egr-Let-7 Esc-Let-7 Ete-Let-7-P2c2 Gga-Let-7-P2c2 Gja-Let-7-P2c2 Gmo-Let-7-P2c2a Gmo-Let-7-P2c2b Gpa-Let-7 Gsa-Let-7 Gsp-Let-7 Hme-Let-7 Hmi-Let-7 Hru-Let-7 Isc-Let-7 Laf-Let-7-P2c2 Lan-Let-7 Lch-Let-7-P2c2 Lgi-Let-7 Lhy-Let-7 Llo-Let-7 Loc-Let-7-P2c2 Mal-Let-7-P2c2b Mdo-Let-7-P2c2 Mgi-Let-7 Mml-Let-7-P2c2 Mmr-Let-7-P2c2 Mmu-Let-7-P2c2 Mom-Let-7 Mun-Let-7-P2c2 Neu-Let-7-P2c2 Npo-Let-7 Oan-Let-7-P2c2 Obi-Let-7 Ocu-Let-7-P2c2 Ofu-Let-7 Ovu-Let-7 Pab-Let-7-P2c2 Pau-Let-7 Pbv-Let-7-P2c2 Pca-Let-7 Pcr-Let-7 Pdu-Let-7 Pfl-Let-7 Ple-Let-7 Pmi-Let-7 Pve-Let-7 Rno-Let-7-P2c2 Rph-Let-7 Sha-Let-7-P2c2 Sko-Let-7 Sma-Let-7 Sne-Let-7 Snu-Let-7 Spt-Let-7-P2c2 Spu-Let-7 Sro-Let-7 Sto-Let-7-P2c2 Tca-Let-7 Tgu-Let-7-P2c2 Tni-Let-7-P2c2a Tni-Let-7-P2c2b Tur-Let-7 War-Let-7 Xbo-Let-7 Xla-Let-7-P2c2 Xtr-Let-7-P2c2

Node of Origin (locus)

Gnathostomata

Node of Origin (family)

Bilateria

Genome context
(hg38)

chr12: 62603691-62603767 [+] UCSC Ensembl

Precursor
(pre-Mir +30nt flank)

CCCGUGCCUCCCCGACACCAUGGCCCUGGCUGAGGUAGUAGUUUGUGCUGUUGGUCGGGUUGUGACAUUGCCCGCUGUGGAGAUAACUGCGCAAGCUACUGCCUUGCUAGUGCUGGUGAUGCUCAGCGCCGCGGAGG

Get precursor sequence

Structure

        10            20        30        40        50        60        
CCCGUGCCUCCCCGACA----|  UG  C     U                 U   GGUCGGGUUGUGACA 
                     CCA  GC CUGGC GAGGUAGUAGUUUGUGC GUU               U
                     GGU  CG GAUCG UUCCGUCAUCGAACGCG CAA               U
GGAGGCGCCGCGACUCGUAGU^  --  U     -                 U   UAGAGGUGUCGCCCG 
     130       120         110        100        90        80        70

Deep sequencing

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Comment

Although there is a templated thymidine at the 3' end of the 3p arm, the post-transcriptional addition of a terminal 3' uridine is supported by the CAGE data from de Rie et al. (2017). All other vertebrates are treated accordingly.

3' NTU

Yes

Motifs

CNNC at 3p(+17)

Tissue expression

Dc	Dc	Dr	Dr	Xp	Xp	Bl	Br	Br	Ce	Ce	Co	Fo	He	Ki	Le	Li	Li	Lu	Pa	Pl	Pl	Sk	Sk	Sk	Sm	Sp	Sp	St	Te	Th	Ut

Mature sequence

Hsa-Let-7-P2c2_5p

mirBase accession

MIMAT0000415

Sequence

0- UGAGGUAGUAGUUUGUGCUGUU -22

Get sequence

Proposed targets

microrna.org: MIMAT0000415
TargetScanVert: hsa-let-7i-5p
TargetMiner: hsa-let-7i-5p
miRDB: MIMAT0000415

Star sequence

Hsa-Let-7-P2c2_3p*

mirBase accession

MIMAT0004585

Sequence

56- CUGCGCAAGCUACUGCCUUGC -77

Get sequence

Proposed targets

microrna.org: MIMAT0004585
TargetScanVert: hsa-let-7i-3p
TargetMiner: hsa-let-7i-3p
miRDB: MIMAT0004585