Let-7-P2b1

MirGeneDB ID

Hsa-Let-7-P2b1

Family name

LET-7 (all species)

Seed

GAGGUAG

Species

Human (Homo sapiens)

MiRBase ID

hsa-let-7f-1

Paralogues

Hsa-Let-7-P1b Hsa-Let-7-P1c Hsa-Let-7-P1d Hsa-Let-7-P2a1 Hsa-Let-7-P2a2 Hsa-Let-7-P2a3 Hsa-Let-7-P2b2 Hsa-Let-7-P2b3 Hsa-Let-7-P2c1 Hsa-Let-7-P2c2 Hsa-Let-7-P2c3

Orthologues

Aae-Let-7 Aca-Let-7-P2b1 Aga-Let-7 Agr-Let-7 Ami-Let-7-P2b1 Bge-Let-7 Bko-Let-7 Bpl-Let-7 Bta-Let-7-P2b1 Cfa-Let-7-P2b1 Cja-Let-7-P2b1 Cli-Let-7-P2b1 Cpi-Let-7-P2b1 Cpo-Let-7-P2b1 Cte-Let-7 Dan-Let-7 Dlo-Let-7 Dma-Let-7 Dme-Let-7 Dmo-Let-7 Dno-Let-7-P2b1 Dpu-Let-7 Dre-Let-7-P2b1a Dsi-Let-7 Dya-Let-7 Eba-Let-7 Eca-Let-7-P2b1 Egr-Let-7 Esc-Let-7 Ete-Let-7-P2b1 Gga-Let-7-P2b1 Gja-Let-7-P2b1 Gmo-Let-7-P2b1a Gpa-Let-7 Gsa-Let-7 Gsp-Let-7 Hme-Let-7 Hmi-Let-7 Hru-Let-7 Isc-Let-7 Laf-Let-7-P2b1 Lan-Let-7 Lch-Let-7-P2b1 Lgi-Let-7 Lhy-Let-7 Llo-Let-7 Loc-Let-7-P2b1 Mal-Let-7-P2b1a Mdo-Let-7-P2b1 Mgi-Let-7 Mml-Let-7-P2b1 Mmr-Let-7-P2b1 Mmu-Let-7-P2b1 Mom-Let-7 Mun-Let-7-P2b1 Neu-Let-7-P2b1 Npo-Let-7 Oan-Let-7-P2b1 Obi-Let-7 Ocu-Let-7-P2b1 Ofu-Let-7 Ovu-Let-7 Pab-Let-7-P2b1 Pau-Let-7 Pbv-Let-7-P2b1 Pca-Let-7 Pcr-Let-7 Pdu-Let-7 Pfl-Let-7 Ple-Let-7 Pmi-Let-7 Pve-Let-7 Rno-Let-7-P2b1 Rph-Let-7 Sha-Let-7-P2b1 Sko-Let-7 Sma-Let-7 Sne-Let-7 Snu-Let-7 Spt-Let-7-P2b1 Spu-Let-7 Sro-Let-7 Tca-Let-7 Tgu-Let-7-P2b1 Tur-Let-7 War-Let-7 Xbo-Let-7

Node of Origin (locus)

Gnathostomata

Node of Origin (family)

Bilateria

Genome context
(hg38)

chr9: 94176353-94176429 [+] UCSC Ensembl

Clustered miRNAs
(< 50kb from Let-7-P2b1)

Let-7-P2a1 chr9: 94175962-94176033 [+] UCSC Ensembl
Let-7-P2b1 chr9: 94176353-94176429 [+] UCSC Ensembl
Let-7-P2c1 chr9: 94178841-94178915 [+] UCSC Ensembl

Precursor
(pre-Mir +30nt flank)

AUUCCAGAAGAAAACAUUGCUCUAUCAGAGUGAGGUAGUAGAUUGUAUAGUUGUGGGGUAGUGAUUUUACCCUGUUCAGGAGAUAACUAUACAAUCUAUUGCCUUCCCUGAGGAGUAGACUUGCUGCAUUAUUUUCU

Get precursor sequence

Structure

        10           20        30        40        50        60        
AUUCCAGAAGAAAACAU---|     A    AGU                     GUGGGGUAGUGAUUU 
                    UGCUCU UCAG   GAGGUAGUAGAUUGUAUAGUU               U
                    AUGAGG AGUC   UUCCGUUAUCUAACAUAUCAA               A
UCUUUUAUUACGUCGUUCAG^     -    CC-                     UAGAGGACUUGUCCC 
     130       120        110        100        90        80        70

Deep sequencing

Go to detailed chart

3' NTU

Yes

Motifs

CNNC at 3p(+17), UGUG in loop

Tissue expression

Dc	Dc	Dr	Dr	Xp	Xp	Bl	Br	Br	Ce	Ce	Co	Fo	He	Ki	Le	Li	Li	Lu	Pa	Pl	Pl	Sk	Sk	Sk	Sm	Sp	Sp	St	Te	Th	Ut

Mature sequence

Hsa-Let-7-P2b1_5p

mirBase accession

MIMAT0000067

Sequence

0- UGAGGUAGUAGAUUGUAUAGUU -22

Get sequence

Proposed targets

microrna.org: MIMAT0000067
TargetScanVert: hsa-let-7f-5p
TargetMiner: hsa-let-7f-5p
miRDB: MIMAT0000067

Star sequence

Hsa-Let-7-P2b1_3p*

mirBase accession

MIMAT0004486

Sequence

56- CUAUACAAUCUAUUGCCUUCC -77

Get sequence

Proposed targets

microrna.org: MIMAT0004486
TargetScanVert: hsa-let-7f-1-3p
TargetMiner: hsa-let-7f-1-3p
miRDB: MIMAT0004486