MirGeneDB 3.0
MirGeneDB ID

Hsa-Let-7-P2c1

Family name LET-7 (all species)
Seed GAGGUAG
Species Human (Homo sapiens)
MiRBase ID hsa-let-7d
Paralogues Hsa-Let-7-P1b  Hsa-Let-7-P1c  Hsa-Let-7-P1d  Hsa-Let-7-P2a1  Hsa-Let-7-P2a2  Hsa-Let-7-P2a3  Hsa-Let-7-P2b1  Hsa-Let-7-P2b2  Hsa-Let-7-P2b3  Hsa-Let-7-P2c2  Hsa-Let-7-P2c3 
Orthologues Aae-Let-7  Aca-Let-7-P2c1  Aga-Let-7  Agr-Let-7  Ami-Let-7-P2c1  Bge-Let-7  Bko-Let-7  Bpl-Let-7  Bta-Let-7-P2c1  Cfa-Let-7-P2c1  Cja-Let-7-P2c1  Cli-Let-7-P2c1  Cmi-Let-7-P2c1  Cpi-Let-7-P2c1  Cpo-Let-7-P2c1  Cte-Let-7  Dan-Let-7  Dlo-Let-7  Dma-Let-7  Dme-Let-7  Dmo-Let-7  Dno-Let-7-P2c1  Dpu-Let-7  Dsi-Let-7  Dya-Let-7  Eba-Let-7  Eca-Let-7-P2c1  Egr-Let-7  Esc-Let-7  Ete-Let-7-P2c1  Gga-Let-7-P2c1  Gja-Let-7-P2c1  Gpa-Let-7  Gsa-Let-7  Gsp-Let-7  Hme-Let-7  Hmi-Let-7  Hru-Let-7  Isc-Let-7  Laf-Let-7-P2c1  Lan-Let-7  Lch-Let-7-P2c1  Lgi-Let-7  Lhy-Let-7  Llo-Let-7  Loc-Let-7-P2c1  Mdo-Let-7-P2c1  Mgi-Let-7  Mml-Let-7-P2c1  Mmr-Let-7-P2c1  Mmu-Let-7-P2c1  Mom-Let-7  Mun-Let-7-P2c1  Neu-Let-7-P2c1  Npo-Let-7  Oan-Let-7-P2c1  Obi-Let-7  Ocu-Let-7-P2c1  Ofu-Let-7  Ovu-Let-7  Pab-Let-7-P2c1  Pau-Let-7  Pbv-Let-7-P2c1  Pca-Let-7  Pcr-Let-7  Pdu-Let-7  Pfl-Let-7  Ple-Let-7  Pmi-Let-7  Pve-Let-7  Rno-Let-7-P2c1  Rph-Let-7  Sha-Let-7-P2c1  Sko-Let-7  Sma-Let-7  Sne-Let-7  Snu-Let-7  Spt-Let-7-P2c1  Spu-Let-7  Sro-Let-7  Sto-Let-7-P2c1  Tca-Let-7  Tgu-Let-7-P2c1  Tur-Let-7  War-Let-7  Xbo-Let-7 
Node of Origin (locus) Gnathostomata
Node of Origin (family) Bilateria
Genome context
(hg38)		 chr9: 94178841-94178915 [+] UCSC Ensembl
Clustered miRNAs
(< 50kb from Let-7-P2c1)		 Let-7-P2a1 chr9: 94175962-94176033 [+] UCSC Ensembl
Let-7-P2b1 chr9: 94176353-94176429 [+] UCSC Ensembl
Let-7-P2c1 chr9: 94178841-94178915 [+] UCSC Ensembl
Precursor
(pre-Mir +30nt flank)
CAGCAAGAAAAAAAAAAUGGGUUCCUAGGAAGAGGUAGUAGGUUGCAUAGUUUUAGGGCAGGGAUUUUGCCCACAAGGAGGUAACUAUACGACCUGCUGCCUUUCUUAGGGCCUUAUUAUUCACCGAUAACCUGU
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Structure
        10          20        30        40        50        60       
CAGCAAGAAAAAAAAAA--|   UU       A              C      UUAGGGCAGGGAUU 
                   UGGG  CCUAGGA GAGGUAGUAGGUUG AUAGUU              U
                   AUUC  GGAUUCU UUCCGUCGUCCAGC UAUCAA              U
UGUCCAAUAGCCACUUAUU^   CG       -              A      UGGAGGAACACCCG 
   130       120       110        100        90        80        70
Deep sequencing
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CommentAlthough there is a templated thymidine at the 3' end of the 3p arm, the post-transcriptional addition of a terminal 3' uridine is supported by the CAGE data from de Rie et al. (2017). All other vertebrates are treated accordingly.
3' NTU Yes
MotifsCNNC at 3p(+17)
Tissue expression
-   +
Dc Dc Dr Dr Xp Xp Bl Br Br Ce Ce Co Fo He Ki Le Li Li Lu Pa Pl Pl Sk Sk Sk Sm Sp Sp St Te Th Ut
Mature sequence

Hsa-Let-7-P2c1_5p
mirBase accessionMIMAT0000065
Sequence 
0- AGAGGUAGUAGGUUGCAUAGUU -22
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Proposed targets microrna.org: MIMAT0000065
TargetScanVert: hsa-let-7d-5p
TargetMiner: hsa-let-7d-5p
miRDB: MIMAT0000065
Star sequence

Hsa-Let-7-P2c1_3p*
mirBase accessionMIMAT0004484
Sequence 
54- CUAUACGACCUGCUGCCUUUC -75
Get sequence
Proposed targets microrna.org: MIMAT0004484
TargetScanVert: hsa-let-7d-3p
TargetMiner: hsa-let-7d-3p
miRDB: MIMAT0004484