Let-7-P1c

MirGeneDB ID

Hsa-Let-7-P1c

Family name

LET-7 (all species)

Seed

GAGGUAG

Species

Human (Homo sapiens)

MiRBase ID

hsa-let-7c

Paralogues

Hsa-Let-7-P1b Hsa-Let-7-P1d Hsa-Let-7-P2a1 Hsa-Let-7-P2a2 Hsa-Let-7-P2a3 Hsa-Let-7-P2b1 Hsa-Let-7-P2b2 Hsa-Let-7-P2b3 Hsa-Let-7-P2c1 Hsa-Let-7-P2c2 Hsa-Let-7-P2c3

Orthologues

Aae-Let-7 Aca-Let-7-P1c Ami-Let-7-P1c Bge-Let-7 Bpl-Let-7 Bta-Let-7-P1c Cfa-Let-7-P1c Cgi-Let-7 Cin-Let-7-P1 Cli-Let-7-P1c Cpi-Let-7-P1c Cpo-Let-7-P1c Cte-Let-7 Dan-Let-7 Dma-Let-7 Dme-Let-7 Dmo-Let-7 Dno-Let-7-P1c Dpu-Let-7 Dre-Let-7-P1c1 Dre-Let-7-P1c2 Dsi-Let-7 Dya-Let-7 Esc-Let-7 Ete-Let-7-P1c Gga-Let-7-P1c Gja-Let-7-P1c Gmo-Let-7-P1c2 Hme-Let-7 Isc-Let-7 Lan-Let-7 Lch-Let-7-P1c Lgi-Let-7 Loc-Let-7-P1c Mal-Let-7-P1c2 Mml-Let-7-P1c Mmu-Let-7-P1c Mun-Let-7-P1c Npo-Let-7 Oan-Let-7-P1c Obi-Let-7 Ocu-Let-7-P1c Ovu-Let-7 Pbv-Let-7-P1c Pfl-Let-7 Pmi-Let-7 Rno-Let-7-P1c Sha-Let-7-P1c Sko-Let-7 Spt-Let-7-P1c Spu-Let-7 Sto-Let-7-P1c Tca-Let-7 Tgu-Let-7-P1c Xbo-Let-7 Xla-Let-7-P1c3 Xla-Let-7-P1c4 Xtr-Let-7-P1c

Node of Origin (locus)

Gnathostomata

Node of Origin (family)

Bilateria

Genome context
(hg38)

chr21: 16539838-16539904 [+] UCSC Ensembl

Clustered miRNAs
(< 50kb from Let-7-P1c)

Mir-10-P2c chr21: 16539101-16539159 [+] UCSC Ensembl
Let-7-P1c chr21: 16539838-16539904 [+] UCSC Ensembl

Precursor
(pre-Mir +30nt flank)

AGCAACAUUGGAAGCUGUGUGCAUCCGGGUUGAGGUAGUAGGUUGUAUGGUUUAGAGUUACACCCUGGGAGUUAACUGUACAACCUUCUAGCUUUCCUUGGAGCACACUUGAGCCGUCGAGGAAUUC

Get precursor sequence

Structure

        10           20        30        40        50        60   
AGCAACAUUGGAAGCUG---|    A      UU   G   U             UAGAGUUACA 
                    UGUGC UCCGGG  GAG UAG AGGUUGUAUGGUU          \
                    ACACG AGGUUC  UUC AUC UCCAACAUGUCAA          C
CUUAAGGAGCUGCCGAGUUC^    -      CU   G   U             UUGAGGGUCC 
     120       110        100        90        80        70

Deep sequencing

Go to detailed chart

3' NTU

Motifs

CNNC at 3p(+17)

Tissue expression

1-	1-	1-	1-	1-	1-	1-	1-	1-	1-	1-	1-	1-	2-	2-	2-	2-	2-	2-	2-	2-	2-	2-	2-	3-	3-	3-	4-	4-	4-	4-	4-	4-	4-	4-	4-	4-	4-	4-	4-	4-	4-	4-	4-	4-	5-	5-	5-	5-	5-	5-	5-	6-	6-	6-	6-	6-

Mature sequence

Hsa-Let-7-P1c_5p

mirBase accession

MIMAT0000064

Sequence

0- UGAGGUAGUAGGUUGUAUGGUU -22

Get sequence

Proposed targets

microrna.org: MIMAT0000064
TargetScanVert: hsa-let-7c-5p
miRDB: MIMAT0000064

Star sequence

Hsa-Let-7-P1c_3p*

mirBase accession

MIMAT0026472

Sequence

45- CUGUACAACCUUCUAGCUUUCC -67

Get sequence

Proposed targets

TargetScanVert: hsa-let-7c-3p
miRDB: MIMAT0026472