Let-7-P1c

MirGeneDB ID

Hsa-Let-7-P1c

Family name

LET-7 (all species)

Seed

GAGGUAG

Species

Human (Homo sapiens)

MiRBase ID

hsa-let-7c

Paralogues

Hsa-Let-7-P1b Hsa-Let-7-P1d Hsa-Let-7-P2a1 Hsa-Let-7-P2a2 Hsa-Let-7-P2a3 Hsa-Let-7-P2b1 Hsa-Let-7-P2b2 Hsa-Let-7-P2b3 Hsa-Let-7-P2c1 Hsa-Let-7-P2c2 Hsa-Let-7-P2c3

Orthologues

Aae-Let-7 Aca-Let-7-P1c Aga-Let-7 Agr-Let-7 Ami-Let-7-P1c Bge-Let-7 Bko-Let-7 Bpl-Let-7 Bta-Let-7-P1c Cfa-Let-7-P1c Cin-Let-7-P1 Cja-Let-7-P1c Cli-Let-7-P1c Cpi-Let-7-P1c Cpo-Let-7-P1c Cte-Let-7 Dan-Let-7 Dlo-Let-7 Dma-Let-7 Dme-Let-7 Dmo-Let-7 Dno-Let-7-P1c Dpu-Let-7 Dre-Let-7-P1c1 Dre-Let-7-P1c2 Dsi-Let-7 Dya-Let-7 Eba-Let-7 Eca-Let-7-P1c Egr-Let-7 Esc-Let-7 Ete-Let-7-P1c Gga-Let-7-P1c Gja-Let-7-P1c Gmo-Let-7-P1c2 Gpa-Let-7 Gsa-Let-7 Gsp-Let-7 Hme-Let-7 Hmi-Let-7 Hru-Let-7 Isc-Let-7 Laf-Let-7-P1c Lan-Let-7 Lch-Let-7-P1c Lgi-Let-7 Lhy-Let-7 Llo-Let-7 Loc-Let-7-P1c Mal-Let-7-P1c2 Mgi-Let-7 Mml-Let-7-P1c Mmr-Let-7-P1c Mmu-Let-7-P1c Mom-Let-7 Mun-Let-7-P1c Neu-Let-7-P1c Npo-Let-7 Oan-Let-7-P1c Obi-Let-7 Ocu-Let-7-P1c Ofu-Let-7 Ovu-Let-7 Pab-Let-7-P1c Pau-Let-7 Pbv-Let-7-P1c Pca-Let-7 Pcr-Let-7 Pdu-Let-7 Pfl-Let-7 Ple-Let-7 Pmi-Let-7 Pve-Let-7 Rno-Let-7-P1c Rph-Let-7 Sha-Let-7-P1c Sko-Let-7 Sma-Let-7 Sne-Let-7 Snu-Let-7 Spt-Let-7-P1c Spu-Let-7 Sro-Let-7 Sto-Let-7-P1c Tca-Let-7 Tgu-Let-7-P1c Tur-Let-7 War-Let-7 Xbo-Let-7 Xla-Let-7-P1c3 Xla-Let-7-P1c4 Xtr-Let-7-P1c

Node of Origin (locus)

Gnathostomata

Node of Origin (family)

Bilateria

Genome context
(hg38)

chr21: 16539838-16539904 [+] UCSC Ensembl

Clustered miRNAs
(< 50kb from Let-7-P1c)

Mir-10-P2c chr21: 16539101-16539159 [+] UCSC Ensembl
Let-7-P1c chr21: 16539838-16539904 [+] UCSC Ensembl

Precursor
(pre-Mir +30nt flank)

AGCAACAUUGGAAGCUGUGUGCAUCCGGGUUGAGGUAGUAGGUUGUAUGGUUUAGAGUUACACCCUGGGAGUUAACUGUACAACCUUCUAGCUUUCCUUGGAGCACACUUGAGCCGUCGAGGAAUUC

Get precursor sequence

Structure

        10           20        30        40        50        60   
AGCAACAUUGGAAGCUG---|    A      UU   G   U             UAGAGUUACA 
                    UGUGC UCCGGG  GAG UAG AGGUUGUAUGGUU          \
                    ACACG AGGUUC  UUC AUC UCCAACAUGUCAA          C
CUUAAGGAGCUGCCGAGUUC^    -      CU   G   U             UUGAGGGUCC 
     120       110        100        90        80        70

Deep sequencing

Go to detailed chart

3' NTU

Motifs

CNNC at 3p(+17)

Tissue expression

Dc	Dc	Dr	Dr	Xp	Xp	Bl	Br	Br	Ce	Ce	Co	Fo	He	Ki	Le	Li	Li	Lu	Pa	Pl	Pl	Sk	Sk	Sk	Sm	Sp	Sp	St	Te	Th	Ut

Mature sequence

Hsa-Let-7-P1c_5p

mirBase accession

MIMAT0000064

Sequence

0- UGAGGUAGUAGGUUGUAUGGUU -22

Get sequence

Proposed targets

microrna.org: MIMAT0000064
TargetScanVert: hsa-let-7c-5p
miRDB: MIMAT0000064

Star sequence

Hsa-Let-7-P1c_3p*

mirBase accession

MIMAT0026472

Sequence

45- CUGUACAACCUUCUAGCUUUCC -67

Get sequence

Proposed targets

TargetScanVert: hsa-let-7c-3p
miRDB: MIMAT0026472