Let-7-P1b

MirGeneDB ID

Hsa-Let-7-P1b

Family name

LET-7 (all species)

Seed

GAGGUAG

Species

Human (Homo sapiens)

MiRBase ID

hsa-let-7e

Paralogues

Hsa-Let-7-P1c Hsa-Let-7-P1d Hsa-Let-7-P2a1 Hsa-Let-7-P2a2 Hsa-Let-7-P2a3 Hsa-Let-7-P2b1 Hsa-Let-7-P2b2 Hsa-Let-7-P2b3 Hsa-Let-7-P2c1 Hsa-Let-7-P2c2 Hsa-Let-7-P2c3

Orthologues

Aae-Let-7 Aca-Let-7-P1b Aga-Let-7 Agr-Let-7 Ami-Let-7-P1b Bge-Let-7 Bko-Let-7 Bpl-Let-7 Bta-Let-7-P1b Cfa-Let-7-P1b Cin-Let-7-P1 Cja-Let-7-P1b Cpi-Let-7-P1b Cpo-Let-7-P1b Cte-Let-7 Dan-Let-7 Dlo-Let-7 Dma-Let-7 Dme-Let-7 Dmo-Let-7 Dpu-Let-7 Dre-Let-7-P1b1 Dre-Let-7-P1b2 Dsi-Let-7 Dya-Let-7 Eba-Let-7 Eca-Let-7-P1b Egr-Let-7 Esc-Let-7 Ete-Let-7-P1b Gja-Let-7-P1b Gmo-Let-7-P1b1 Gmo-Let-7-P1b2 Gpa-Let-7 Gsa-Let-7 Gsp-Let-7 Hme-Let-7 Hmi-Let-7 Hru-Let-7 Isc-Let-7 Laf-Let-7-P1b Lan-Let-7 Lch-Let-7-P1b Lgi-Let-7 Lhy-Let-7 Llo-Let-7 Loc-Let-7-P1b Mal-Let-7-P1b1 Mal-Let-7-P1b2 Mdo-Let-7-P1b Mgi-Let-7 Mml-Let-7-P1b Mmr-Let-7-P1b Mmu-Let-7-P1b Mom-Let-7 Mun-Let-7-P1b Npo-Let-7 Oan-Let-7-P1b Obi-Let-7 Ocu-Let-7-P1b Ofu-Let-7 Ovu-Let-7 Pab-Let-7-P1b Pau-Let-7 Pbv-Let-7-P1b Pca-Let-7 Pcr-Let-7 Pdu-Let-7 Pfl-Let-7 Ple-Let-7 Pmi-Let-7 Pve-Let-7 Rno-Let-7-P1b Rph-Let-7 Sha-Let-7-P1b Sko-Let-7 Sma-Let-7 Sne-Let-7 Snu-Let-7 Spt-Let-7-P1b Spu-Let-7 Sro-Let-7 Sto-Let-7-P1b Tca-Let-7 Tni-Let-7-P1b1 Tni-Let-7-P1b2 Tur-Let-7 War-Let-7 Xbo-Let-7 Xla-Let-7-P1b3 Xla-Let-7-P1b4 Xtr-Let-7-P1b

Node of Origin (locus)

Gnathostomata

Node of Origin (family)

Bilateria

Genome context
(hg38)

chr19: 51692793-51692859 [+] UCSC Ensembl

Clustered miRNAs
(< 50kb from Let-7-P1b)

Mir-10-P2b chr19: 51692618-51692677 [+] UCSC Ensembl
Let-7-P1b chr19: 51692793-51692859 [+] UCSC Ensembl
Mir-10-P3b chr19: 51693268-51693327 [+] UCSC Ensembl

Precursor
(pre-Mir +30nt flank)

GGGUCUGUCCACCUGCCGCGCCCCCCGGGCUGAGGUAGGAGGUUGUAUAGUUGAGGAGGACACCCAAGGAGAUCACUAUACGGCCUCCUAGCUUUCCCCAGGCUGCGCCCUGCACGGGACGGGGCCC

Get precursor sequence

Structure

        10          20        30        40        50        60   
GGGUCUGUCCACCUGCC--|   CC  C   CU   G                UGAGGAGGACA 
                   GCGC  CC GGG  GAG UAGGAGGUUGUAUAGU           \
                   CGCG  GG CCC  UUC AUCCUCCGGCAUAUCA           C
CCCGGGGCAGGGCACGUCC^   UC  A   CU   G                CUAGAGGAACC 
     120       110       100        90        80        70

Deep sequencing

Go to detailed chart

3' NTU

Motifs

Tissue expression

Dc	Dc	Dr	Dr	Xp	Xp	Bl	Br	Br	Ce	Ce	Co	Fo	He	Ki	Le	Li	Li	Lu	Pa	Pl	Pl	Sk	Sk	Sk	Sm	Sp	Sp	St	Te	Th	Ut

Mature sequence

Hsa-Let-7-P1b_5p

mirBase accession

MIMAT0000066

Sequence

0- UGAGGUAGGAGGUUGUAUAGUU -22

Get sequence

Proposed targets

microrna.org: MIMAT0000066
TargetScanVert: hsa-let-7e-5p
TargetMiner: hsa-let-7e-5p
miRDB: MIMAT0000066

Star sequence

Hsa-Let-7-P1b_3p*

mirBase accession

MIMAT0004485

Sequence

45- CUAUACGGCCUCCUAGCUUUCC -67

Get sequence

Proposed targets

microrna.org: MIMAT0004485
TargetScanVert: hsa-let-7e-3p
TargetMiner: hsa-let-7e-3p
miRDB: MIMAT0004485