Let-7-P2c1

MirGeneDB ID

Mml-Let-7-P2c1

Family name

LET-7 (all species)

Seed

GAGGUAG

Species

Rhesus monkey (Macaca mulatta)

MiRBase ID

mml-let-7d

Paralogues

Mml-Let-7-P1b Mml-Let-7-P1c Mml-Let-7-P1d Mml-Let-7-P2a1 Mml-Let-7-P2a2 Mml-Let-7-P2a3 Mml-Let-7-P2b1 Mml-Let-7-P2b2 Mml-Let-7-P2b3 Mml-Let-7-P2c2 Mml-Let-7-P2c3

Orthologues

Aae-Let-7 Aca-Let-7-P2c1 Aga-Let-7 Agr-Let-7 Ami-Let-7-P2c1 Bge-Let-7 Bko-Let-7 Bpl-Let-7 Bta-Let-7-P2c1 Cfa-Let-7-P2c1 Cja-Let-7-P2c1 Cli-Let-7-P2c1 Cmi-Let-7-P2c1 Cpi-Let-7-P2c1 Cpo-Let-7-P2c1 Cte-Let-7 Dan-Let-7 Dlo-Let-7 Dma-Let-7 Dme-Let-7 Dmo-Let-7 Dno-Let-7-P2c1 Dpu-Let-7 Dsi-Let-7 Dya-Let-7 Eba-Let-7 Eca-Let-7-P2c1 Egr-Let-7 Esc-Let-7 Ete-Let-7-P2c1 Gga-Let-7-P2c1 Gja-Let-7-P2c1 Gpa-Let-7 Gsa-Let-7 Gsp-Let-7 Hme-Let-7 Hmi-Let-7 Hru-Let-7 Hsa-Let-7-P2c1 Isc-Let-7 Laf-Let-7-P2c1 Lan-Let-7 Lch-Let-7-P2c1 Lgi-Let-7 Lhy-Let-7 Llo-Let-7 Loc-Let-7-P2c1 Mdo-Let-7-P2c1 Mgi-Let-7 Mmr-Let-7-P2c1 Mmu-Let-7-P2c1 Mom-Let-7 Mun-Let-7-P2c1 Neu-Let-7-P2c1 Npo-Let-7 Oan-Let-7-P2c1 Obi-Let-7 Ocu-Let-7-P2c1 Ofu-Let-7 Ovu-Let-7 Pab-Let-7-P2c1 Pau-Let-7 Pbv-Let-7-P2c1 Pca-Let-7 Pcr-Let-7 Pdu-Let-7 Pfl-Let-7 Ple-Let-7 Pmi-Let-7 Pve-Let-7 Rno-Let-7-P2c1 Rph-Let-7 Sha-Let-7-P2c1 Sko-Let-7 Sma-Let-7 Sne-Let-7 Snu-Let-7 Spt-Let-7-P2c1 Spu-Let-7 Sro-Let-7 Sto-Let-7-P2c1 Tca-Let-7 Tgu-Let-7-P2c1 Tur-Let-7 War-Let-7 Xbo-Let-7

Node of Origin (locus)

Gnathostomata

Node of Origin (family)

Bilateria

Genome context
(GCA_003339765.3_Mmul_10_traces)

CM014350.1: 109114037-109114111 [+] UCSC Ensembl

Clustered miRNAs
(< 50kb from Let-7-P2c1)

Let-7-P2a1 CM014350.1: 109111168-109111239 [+] UCSC Ensembl
Let-7-P2b1 CM014350.1: 109111559-109111635 [+] UCSC Ensembl
Let-7-P2c1 CM014350.1: 109114037-109114111 [+] UCSC Ensembl

Precursor
(pre-Mir +30nt flank)

CAGCAAGAAAAAAAAAAUGGGUUCCUAGGAAGAGGUAGUAGGUUGCAUAGUUUUAGGGCAGGGAUUUUGCCCACAAGGAGGUAACUAUACGACCUGCUGCCUUUCUUAGGGCCUUAUUAUUCAACGGUAACCUGU

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Structure

        10          20        30        40        50        60       
CAGCAAGAAAAAAAAAA--|   UU       A              C      UUAGGGCAGGGAUU 
                   UGGG  CCUAGGA GAGGUAGUAGGUUG AUAGUU              U
                   AUUC  GGAUUCU UUCCGUCGUCCAGC UAUCAA              U
UGUCCAAUGGCAACUUAUU^   CG       -              A      UGGAGGAACACCCG 
   130       120       110        100        90        80        70

Deep sequencing

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Comment

This is a Group 2 in human according to Kim et al. (2017) but because there is a templated 3' U it is not possible according to read data to classify it as such in other taxa although the secondary structure is consistent with this categorization.

3' NTU

Yes

Motifs

CNNC at 3p(+17)

Tissue expression

Bo	Br	Br	Br	He	Ki	Li	Lu	Ly	Sk	Sp	Te	Th

Mature sequence

Mml-Let-7-P2c1_5p

mirBase accession

MIMAT0006154

Sequence

0- AGAGGUAGUAGGUUGCAUAGUU -22

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Proposed targets

TargetScanVert: mml-let-7d

Star sequence

Mml-Let-7-P2c1_3p*

mirBase accession

None

Sequence

54- CUAUACGACCUGCUGCCUUUC -75

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