Let-7-P2c1

MirGeneDB ID

Rno-Let-7-P2c1

Family name

LET-7 (all species)

Seed

GAGGUAG

Species

Norway rat (Rattus norvegicus)

MiRBase ID

rno-let-7d

Paralogues

Rno-Let-7-P1b Rno-Let-7-P1c Rno-Let-7-P1d Rno-Let-7-P2a1 Rno-Let-7-P2a2 Rno-Let-7-P2a3 Rno-Let-7-P2b1 Rno-Let-7-P2b2 Rno-Let-7-P2b3 Rno-Let-7-P2c2 Rno-Let-7-P2c3

Orthologues

Aae-Let-7 Aca-Let-7-P2c1 Aga-Let-7 Agr-Let-7 Ami-Let-7-P2c1 Bge-Let-7 Bko-Let-7 Bpl-Let-7 Bta-Let-7-P2c1 Cfa-Let-7-P2c1 Cja-Let-7-P2c1 Cli-Let-7-P2c1 Cmi-Let-7-P2c1 Cpi-Let-7-P2c1 Cpo-Let-7-P2c1 Cte-Let-7 Dan-Let-7 Dlo-Let-7 Dma-Let-7 Dme-Let-7 Dmo-Let-7 Dno-Let-7-P2c1 Dpu-Let-7 Dsi-Let-7 Dya-Let-7 Eba-Let-7 Eca-Let-7-P2c1 Egr-Let-7 Esc-Let-7 Ete-Let-7-P2c1 Gga-Let-7-P2c1 Gja-Let-7-P2c1 Gpa-Let-7 Gsa-Let-7 Gsp-Let-7 Hme-Let-7 Hmi-Let-7 Hru-Let-7 Hsa-Let-7-P2c1 Isc-Let-7 Laf-Let-7-P2c1 Lan-Let-7 Lch-Let-7-P2c1 Lgi-Let-7 Lhy-Let-7 Llo-Let-7 Loc-Let-7-P2c1 Mdo-Let-7-P2c1 Mgi-Let-7 Mml-Let-7-P2c1 Mmr-Let-7-P2c1 Mmu-Let-7-P2c1 Mom-Let-7 Mun-Let-7-P2c1 Neu-Let-7-P2c1 Npo-Let-7 Oan-Let-7-P2c1 Obi-Let-7 Ocu-Let-7-P2c1 Ofu-Let-7 Ovu-Let-7 Pab-Let-7-P2c1 Pau-Let-7 Pbv-Let-7-P2c1 Pca-Let-7 Pcr-Let-7 Pdu-Let-7 Pfl-Let-7 Ple-Let-7 Pmi-Let-7 Pve-Let-7 Rph-Let-7 Sha-Let-7-P2c1 Sko-Let-7 Sma-Let-7 Sne-Let-7 Snu-Let-7 Spt-Let-7-P2c1 Spu-Let-7 Sro-Let-7 Sto-Let-7-P2c1 Tca-Let-7 Tgu-Let-7-P2c1 Tur-Let-7 War-Let-7 Xbo-Let-7

Node of Origin (locus)

Gnathostomata

Node of Origin (family)

Bilateria

Genome context
(rn6)

chr17: 16419993-16420067 [+] UCSC Ensembl

Clustered miRNAs
(< 50kb from Let-7-P2c1)

Let-7-P2a1 chr17: 16417865-16417936 [+] UCSC Ensembl
Let-7-P2b1 chr17: 16418228-16418304 [+] UCSC Ensembl
Let-7-P2c1 chr17: 16419993-16420067 [+] UCSC Ensembl

Precursor
(pre-Mir +30nt flank)

GACCAGCAAGAAUACAGUGGGCUCCUAGGAAGAGGUAGUAGGUUGCAUAGUUUUAGGGCAGAGAUUUUGCCCACAAGGAGUUAACUAUACGACCUGCUGCCUUUCUUAGGGCCUUAUCAUACCAGCAUACAGUUC

Get precursor sequence

Structure

        10           20        30        40        50        60       
GACCAGCAAGAAUACAGU---|   U       A              C      UUAGGGCAGAGAUU 
                     GGGC CCUAGGA GAGGUAGUAGGUUG AUAGUU              U
                     UCCG GGAUUCU UUCCGUCGUCCAGC UAUCAA              U
CUUGACAUACGACCAUACUAU^   -       -              A      UUGAGGAACACCCG 
   130       120        110        100        90        80        70

Deep sequencing

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Comment

This is a Group 2 in human according to Kim et al. (2017) but because there is a templated 3' U it is not possible according to read data to classify it as such in other taxa although the secondary structure is consistent with this categorization.

3' NTU

Yes

Motifs

CNNC at 3p(+17)

Tissue expression

Dr	Dr	Ad	Bi	Bi	Bi	Bi	Br	Br	Br	Br	Ce	Ce	Ce	Ce	Co	Co	Co	Co	Du	Du	Du	Du	Fa	He	He	He	Hi	Hi	Il	Il	Je	Je	Ki	Ki	Ki	Ki	Ki	La	Li	Li	Li	Li	Li	Li	Lu	Me	Me	Mu	Ov	Pa	Pa	Pa	Sk	Sm	So	So	So	So	Sp	St	St	St	St	Te	Te	Th	Ut	Wh

Mature sequence

Rno-Let-7-P2c1_5p

mirBase accession

MIMAT0000562

Sequence

0- AGAGGUAGUAGGUUGCAUAGUU -22

Get sequence

Proposed targets

microrna.org: MIMAT0000562
TargetScanVert: rno-let-7d-5p
miRDB: MIMAT0000562

Star sequence

Rno-Let-7-P2c1_3p*

mirBase accession

MIMAT0000563

Sequence

54- CUAUACGACCUGCUGCCUUUC -75

Get sequence

Proposed targets

microrna.org: MIMAT0000563
TargetScanVert: rno-let-7d-3p
miRDB: MIMAT0000563