Let-7-P2c1

MirGeneDB ID

Gga-Let-7-P2c1

Family name

LET-7 (all species)

Seed

GAGGUAG

Species

Chicken (Gallus gallus)

MiRBase ID

gga-let-7d

Paralogues

Gga-Let-7-P1c Gga-Let-7-P1d Gga-Let-7-P2a1 Gga-Let-7-P2a2 Gga-Let-7-P2a4 Gga-Let-7-P2b1 Gga-Let-7-P2b2 Gga-Let-7-P2b4 Gga-Let-7-P2c2 Gga-Let-7-P2c3

Orthologues

Aae-Let-7 Aca-Let-7-P2c1 Aga-Let-7 Agr-Let-7 Ami-Let-7-P2c1 Bge-Let-7 Bko-Let-7 Bpl-Let-7 Bta-Let-7-P2c1 Cfa-Let-7-P2c1 Cja-Let-7-P2c1 Cli-Let-7-P2c1 Cmi-Let-7-P2c1 Cpi-Let-7-P2c1 Cpo-Let-7-P2c1 Cte-Let-7 Dan-Let-7 Dlo-Let-7 Dma-Let-7 Dme-Let-7 Dmo-Let-7 Dno-Let-7-P2c1 Dpu-Let-7 Dsi-Let-7 Dya-Let-7 Eba-Let-7 Eca-Let-7-P2c1 Egr-Let-7 Esc-Let-7 Ete-Let-7-P2c1 Gja-Let-7-P2c1 Gpa-Let-7 Gsa-Let-7 Gsp-Let-7 Hme-Let-7 Hmi-Let-7 Hru-Let-7 Hsa-Let-7-P2c1 Isc-Let-7 Laf-Let-7-P2c1 Lan-Let-7 Lch-Let-7-P2c1 Lgi-Let-7 Lhy-Let-7 Llo-Let-7 Loc-Let-7-P2c1 Mdo-Let-7-P2c1 Mgi-Let-7 Mml-Let-7-P2c1 Mmr-Let-7-P2c1 Mmu-Let-7-P2c1 Mom-Let-7 Mun-Let-7-P2c1 Neu-Let-7-P2c1 Npo-Let-7 Oan-Let-7-P2c1 Obi-Let-7 Ocu-Let-7-P2c1 Ofu-Let-7 Ovu-Let-7 Pab-Let-7-P2c1 Pau-Let-7 Pbv-Let-7-P2c1 Pca-Let-7 Pcr-Let-7 Pdu-Let-7 Pfl-Let-7 Ple-Let-7 Pmi-Let-7 Pve-Let-7 Rno-Let-7-P2c1 Rph-Let-7 Sha-Let-7-P2c1 Sko-Let-7 Sma-Let-7 Sne-Let-7 Snu-Let-7 Spt-Let-7-P2c1 Spu-Let-7 Sro-Let-7 Sto-Let-7-P2c1 Tca-Let-7 Tgu-Let-7-P2c1 Tur-Let-7 War-Let-7 Xbo-Let-7

Node of Origin (locus)

Gnathostomata

Node of Origin (family)

Bilateria

Genome context
(Gallus_gallus.GRCg6a)

12: 6488759-6488833 [-] UCSC Ensembl

Clustered miRNAs
(< 50kb from Let-7-P2c1)

Let-7-P2c1 12: 6488759-6488833 [-] UCSC Ensembl
Let-7-P2b1 12: 6489795-6489871 [-] UCSC Ensembl
Let-7-P2a1 12: 6490211-6490282 [-] UCSC Ensembl

Precursor
(pre-Mir +30nt flank)

CUGCAGAAAGGAAGCAUUGGGCUCCUAGGAAGAGGUAGUGGGUUGCAUAGUUUUAGGGCAGGGAUUUUGCUCACAAGGAGGUAACUAUACAACCUGCUGCCUUUCUUAGGGCUUUAUUAUAACACCAGGACCAUU

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Structure

        10           20        30        40        50        60       
CUGCAGAAAGGAAGCAUU---|   U       A       UG     C      UUAGGGCAGGGAUU 
                     GGGC CCUAGGA GAGGUAG  GGUUG AUAGUU              U
                     UUCG GGAUUCU UUCCGUC  CCAAC UAUCAA              U
UUACCAGGACCACAAUAUUAU^   -       -       GU     A      UGGAGGAACACUCG 
   130       120        110        100        90        80        70

Deep sequencing

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Comment

This is a Group 2 in human according to Kim et al. (2017) but because there is a templated 3' U it is not possible according to read data to classify it as such in other taxa although the secondary structure is consistent with this categorization.

3' NTU

Yes

Motifs

CNNC at 3p(+17)

Tissue expression

Ad	Ad	Ad	Br	Br	Ce	Ce	Ce	Ce	Gg	He	He	Hy	Hy	Ki	Ki	Li	Li	Lu	Lu	Ov	Pr	Pr	Sc	Sc	Sp	Sp	Te

Mature sequence

Gga-Let-7-P2c1_5p

mirBase accession

MIMAT0001161

Sequence

0- AGAGGUAGUGGGUUGCAUAGUU -22

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Proposed targets

TargetScanVert: gga-let-7d
miRDB: MIMAT0001161

Star sequence

Gga-Let-7-P2c1_3p*

mirBase accession

None

Sequence

54- CUAUACAACCUGCUGCCUUUC -75

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