MirGeneDB 3.0
MirGeneDB ID

Ocu-Let-7-P2c1

Family name LET-7 (all species)
Seed GAGGUAG
Species Rabbit (Oryctolagus cuniculus)
MiRBase ID ocu-let-7d
Paralogues Ocu-Let-7-P1b  Ocu-Let-7-P1c  Ocu-Let-7-P1d  Ocu-Let-7-P2a1  Ocu-Let-7-P2a2  Ocu-Let-7-P2a3  Ocu-Let-7-P2b1  Ocu-Let-7-P2b2  Ocu-Let-7-P2b3  Ocu-Let-7-P2c2  Ocu-Let-7-P2c3 
Orthologues Aae-Let-7  Aca-Let-7-P2c1  Aga-Let-7  Agr-Let-7  Ami-Let-7-P2c1  Bge-Let-7  Bko-Let-7  Bpl-Let-7  Bta-Let-7-P2c1  Cfa-Let-7-P2c1  Cja-Let-7-P2c1  Cli-Let-7-P2c1  Cmi-Let-7-P2c1  Cpi-Let-7-P2c1  Cpo-Let-7-P2c1  Cte-Let-7  Dan-Let-7  Dlo-Let-7  Dma-Let-7  Dme-Let-7  Dmo-Let-7  Dno-Let-7-P2c1  Dpu-Let-7  Dsi-Let-7  Dya-Let-7  Eba-Let-7  Eca-Let-7-P2c1  Egr-Let-7  Esc-Let-7  Ete-Let-7-P2c1  Gga-Let-7-P2c1  Gja-Let-7-P2c1  Gpa-Let-7  Gsa-Let-7  Gsp-Let-7  Hme-Let-7  Hmi-Let-7  Hru-Let-7  Hsa-Let-7-P2c1  Isc-Let-7  Laf-Let-7-P2c1  Lan-Let-7  Lch-Let-7-P2c1  Lgi-Let-7  Lhy-Let-7  Llo-Let-7  Loc-Let-7-P2c1  Mdo-Let-7-P2c1  Mgi-Let-7  Mml-Let-7-P2c1  Mmr-Let-7-P2c1  Mmu-Let-7-P2c1  Mom-Let-7  Mun-Let-7-P2c1  Neu-Let-7-P2c1  Npo-Let-7  Oan-Let-7-P2c1  Obi-Let-7  Ofu-Let-7  Ovu-Let-7  Pab-Let-7-P2c1  Pau-Let-7  Pbv-Let-7-P2c1  Pca-Let-7  Pcr-Let-7  Pdu-Let-7  Pfl-Let-7  Ple-Let-7  Pmi-Let-7  Pve-Let-7  Rno-Let-7-P2c1  Rph-Let-7  Sha-Let-7-P2c1  Sko-Let-7  Sma-Let-7  Sne-Let-7  Snu-Let-7  Spt-Let-7-P2c1  Spu-Let-7  Sro-Let-7  Sto-Let-7-P2c1  Tca-Let-7  Tgu-Let-7-P2c1  Tur-Let-7  War-Let-7  Xbo-Let-7 
Node of Origin (locus) Gnathostomata
Node of Origin (family) Bilateria
Genome context
(oryCun2_add)		 chr1: 71566522-71566596 [+] UCSC Ensembl
Clustered miRNAs
(< 50kb from Let-7-P2c1)		 Let-7-P2a1 chr1: 71563893-71563964 [+] UCSC Ensembl
Let-7-P2b1 chr1: 71564253-71564329 [+] UCSC Ensembl
Let-7-P2c1 chr1: 71566522-71566596 [+] UCSC Ensembl
Precursor
(pre-Mir +30nt flank)
GACCGACAAGAAAAAAAUGGGUUCCUAGGAAGAGGUAGUAGGUUGCAUAGUUUUAGGGCAGGGAUUUUGCCCACAAGGAGGUAACUAUACGACCUGCUGCCUUUCUUAGGGCCUUAUUAUUCCACGGUAACCAGU
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Structure
        10          20        30        40        50        60       
GACCGACAAGAAAAAAA--|   UU       A              C      UUAGGGCAGGGAUU 
                   UGGG  CCUAGGA GAGGUAGUAGGUUG AUAGUU              U
                   AUUC  GGAUUCU UUCCGUCGUCCAGC UAUCAA              U
UGACCAAUGGCACCUUAUU^   CG       -              A      UGGAGGAACACCCG 
   130       120       110        100        90        80        70
Deep sequencing
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CommentThis is a Group 2 in human according to Kim et al. (2017) but because there is a templated 3' U it is not possible according to read data to classify it as such in other taxa although the secondary structure is consistent with this categorization.
3' NTU Yes
MotifsCNNC at 3p(+17)
Tissue expression
-   +
He Ki Te To Wh
Mature sequence

Ocu-Let-7-P2c1_5p
mirBase accessionMIMAT0048082
Sequence 
0- AGAGGUAGUAGGUUGCAUAGUU -22
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Star sequence

Ocu-Let-7-P2c1_3p*
mirBase accessionMIMAT0048083
Sequence 
54- CUAUACGACCUGCUGCCUUUC -75
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