MirGeneDB 3.0
MirGeneDB ID

Hsa-Mir-421-P2

Family name MIR-421 (all species)
Seed UCAACAG
Species Human (Homo sapiens)
MiRBase ID hsa-mir-421
Paralogues Hsa-Mir-421-P1-v1  Hsa-Mir-421-P1-v2 
Orthologues Bta-Mir-421-P2  Cfa-Mir-421-P2  Cja-Mir-421-P2  Eca-Mir-421-P2  Laf-Mir-421-P2  Mml-Mir-421-P2  Mmu-Mir-421-P2  Ocu-Mir-421-P2  Pab-Mir-421-P2  Rno-Mir-421-P2 
Node of Origin (locus) Eutheria
Node of Origin (family) Eutheria
Genome context
(hg38)		 chrX: 74218392-74218448 [-] UCSC Ensembl
Clustered miRNAs
(< 50kb from Mir-421-P2)		 Mir-421-P2 chrX: 74218392-74218448 [-] UCSC Ensembl
Mir-374-P2 chrX: 74218557-74218608 [-] UCSC Ensembl
Precursor
(pre-Mir +30nt flank)
ACAGUGCCUAAUCCGGUGCACAUUGUAGGCCUCAUUAAAUGUUUGUUGAAUGAAAAAAUGAAUCAUCAACAGACAUUAAUUGGGCGCCUGCUCUGUGAUCUCCAUGGGCUCAGCUUG
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Structure
        10          20        30         40        50        
ACAGUGCCUAAUCCGGUG--    UU      -|   UUA            A   AAAA 
                    CACA  GUAGGC CUCA   AAUGUUUGUUGA UGA    \
                    GUGU  CGUCCG GGGU   UUACAGACAACU ACU    A
GUUCGACUCGGGUACCUCUA    CU      C^   UAA            -   AAGU 
     110       100        90        80        70         60
Deep sequencing
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CommentThere is a second Drosha cut -1 on the 3p arm that is monouridylated at the 3' end.
3' NTU No
MotifsUG at 5p(-14)
Tissue expression
-   +
Dc Dc Dr Dr Xp Xp Bl Br Br Ce Ce Co Fo He Ki Le Li Li Lu Pa Pl Pl Sk Sk Sk Sm Sp Sp St Te Th Ut
Star sequence

Hsa-Mir-421-P2_5p*
mirBase accessionNone
Sequence 
0- CUCAUUAAAUGUUUGUUGAAUGA -23
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Mature sequence

Hsa-Mir-421-P2_3p
mirBase accessionMIMAT0003339
Sequence 
34- AUCAACAGACAUUAAUUGGGCGC -57
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Proposed targets microrna.org: MIMAT0003339
TargetScanVert: hsa-miR-421
TargetMiner: hsa-miR-421
miRDB: MIMAT0003339