Mir-10-P2c

MirGeneDB ID

Pbv-Mir-10-P2c

Family name

MIR-10 (all species)

Seed

ACCCGUA

Species

Burmese python (Python bivittatus)

MiRBase ID

pbv-mir-99a

Paralogues

Pbv-Mir-10-P1b-v1 Pbv-Mir-10-P1b-v2 Pbv-Mir-10-P1c-v1 Pbv-Mir-10-P1c-v2 Pbv-Mir-10-P1d-v1 Pbv-Mir-10-P1d-v2 Pbv-Mir-10-P2b Pbv-Mir-10-P2d Pbv-Mir-10-P3b Pbv-Mir-10-P3c Pbv-Mir-10-P3d

Orthologues

Aae-Mir-10-P2 Aca-Mir-10-P2c Adi-Mir-10 Aga-Mir-10-P2 Agr-Mir-10-P2 Ami-Mir-10-P2c Asp-Mir-10 Bfl-Mir-10-P2-v1 Bfl-Mir-10-P2-v2 Bge-Mir-10-P2 Bko-Mir-10-P2 Bla-Mir-10-P2-v1 Bla-Mir-10-P2-v2 Bpl-Mir-10-P2 Bta-Mir-10-P2c Cbr-Mir-10-P2 Cel-Mir-10-P2 Cfa-Mir-10-P2c Cin-Mir-10-P2 Cja-Mir-10-P2c Cli-Mir-10-P2c Cmi-Mir-10-P2c Cpi-Mir-10-P2c Cpo-Mir-10-P2c Cte-Mir-10-P2 Dan-Mir-10-P2 Dgr-Mir-10-P2 Dlo-Mir-10-P2 Dma-Mir-10-P2 Dme-Mir-10-P2 Dmo-Mir-10-P2 Dno-Mir-10-P2c Dpu-Mir-10-P2 Dre-Mir-10-P2c1 Dre-Mir-10-P2c2 Dsi-Mir-10-P2 Dya-Mir-10-P2 Eba-Mir-10-P2 Eca-Mir-10-P2c Ete-Mir-10-P2c Gga-Mir-10-P2c Gja-Mir-10-P2c Gmo-Mir-10-P2c2 Gpa-Mir-10-P2 Gsp-Mir-10-P2 Hru-Mir-10-P2 Hsa-Mir-10-P2c Isc-Mir-10-P2 Laf-Mir-10-P2c Lan-Mir-10-P2 Lch-Mir-10-P2c Lgi-Mir-10-P2 Lhy-Mir-10-P2 Llo-Mir-10-P2 Loc-Mir-10-P2c Mal-Mir-10-P2c2 Mgi-Mir-10-P2 Mml-Mir-10-P2c Mmr-Mir-10-P2c Mmu-Mir-10-P2c Mom-Mir-10-P2 Mun-Mir-10-P2c Neu-Mir-10-P2c Npo-Mir-10-P2 Nve-Mir-10 Oan-Mir-10-P2c Obi-Mir-10-P2 Ocu-Mir-10-P2c Ofu-Mir-10-P2 Ovu-Mir-10-P2 Pab-Mir-10-P2c Pau-Mir-10-P2 Pca-Mir-10-P2 Pdu-Mir-10-P2 Pfl-Mir-10-P2 Ple-Mir-10-P2 Pmi-Mir-10-P2 Pve-Mir-10-P2 Rno-Mir-10-P2c Rph-Mir-10-P2 Sha-Mir-10-P2c Sko-Mir-10-P2 Snu-Mir-10-P2 Spt-Mir-10-P2c Sto-Mir-10-P2c Tca-Mir-10-P2 Tgu-Mir-10-P2c Tur-Mir-10-P2 Xbo-Mir-10-P2 Xbo-Mir-10-P2-as Xla-Mir-10-P2c3 Xla-Mir-10-P2c4 Xtr-Mir-10-P2c

Node of Origin (locus)

Gnathostomata

Node of Origin (family)

Eumetazoa

Genome context
(GCA_000186305.2_Python_molurus_bivittatus)

KE953041.1: 91452-91510 [+]

Clustered miRNAs
(< 50kb from Mir-10-P2c)

Mir-10-P2c KE953041.1: 91452-91510 [+]
Let-7-P1c KE953041.1: 92848-92913 [+]
Mir-10-P3c KE953041.1: 123184-123245 [+]

Precursor
(pre-Mir +30nt flank)

AACUUGUUUCCAUUGGUGCCAAUUGGCAUAAACCCGUAGAUCCGAUCUUGUGGUGAAAUAUAGUGCACAAGCUCGUUUCUAUGGGUCAGUGUCAGUCUGGUGAUUUAACAAGAUUGUAU

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Structure

        10         20         30        40        50         
AACUUGUUUCCAUUGGU-    -|       AA         UC   U      GUGAAA 
                  GCCA AUUGGCAU  ACCCGUAGA  CGA CUUGUG      \
                  UGGU UGACUGUG  UGGGUAUCU  GCU GAACAC      U
UAUGUUAGAACAAUUUAG    C^       AC         UU   C      GUGAUA 
       110       100        90        80        70        60

Deep sequencing

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Comment

Based on the 3' DcRNA reads in human (P2b) and platypus (P2c) it appears that this is a Group 2 miRNA.

3' NTU

Yes

Motifs

UG at 5p(-14), UGUG in loop

Tissue expression

To

Mature sequence

Pbv-Mir-10-P2c_5p

mirBase accession

MIMAT0038895

Sequence

0- AACCCGUAGAUCCGAUCUUGUG -22

Get sequence

Star sequence

Pbv-Mir-10-P2c_3p*

mirBase accession

MIMAT0038896

Sequence

37- CAAGCUCGUUUCUAUGGGUCAG -59

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