MirGeneDB 3.0
MirGeneDB ID

Dre-Let-7-P2b4a

Family name LET-7 (all species)
Seed GAGGUAG
Species Zebrafish (Danio rerio)
MiRBase ID dre-let-7a-5
Paralogues Dre-Let-7-P1b1  Dre-Let-7-P1b2  Dre-Let-7-P1c1  Dre-Let-7-P1c2  Dre-Let-7-P1d1  Dre-Let-7-P1d2  Dre-Let-7-P2a1a  Dre-Let-7-P2a2a  Dre-Let-7-P2a2b  Dre-Let-7-P2a3a  Dre-Let-7-P2a3b  Dre-Let-7-P2a4a  Dre-Let-7-P2a4b  Dre-Let-7-P2b1a  Dre-Let-7-P2b2a  Dre-Let-7-P2b2b  Dre-Let-7-P2b3a  Dre-Let-7-P2b4b  Dre-Let-7-P2c2b  Dre-Let-7-P2c3 
Orthologues Aae-Let-7  Aca-Let-7-P2b4  Aga-Let-7  Agr-Let-7  Ami-Let-7-P2b4  Bge-Let-7  Bko-Let-7  Bpl-Let-7  Cli-Let-7-P2b4  Cmi-Let-7-P2b4  Cpi-Let-7-P2b4  Cte-Let-7  Dan-Let-7  Dlo-Let-7  Dma-Let-7  Dme-Let-7  Dmo-Let-7  Dpu-Let-7  Dsi-Let-7  Dya-Let-7  Eba-Let-7  Egr-Let-7  Esc-Let-7  Gga-Let-7-P2b4  Gja-Let-7-P2b4  Gmo-Let-7-P2b4a  Gmo-Let-7-P2b4b  Gpa-Let-7  Gsa-Let-7  Gsp-Let-7  Hme-Let-7  Hmi-Let-7  Hru-Let-7  Isc-Let-7  Lan-Let-7  Lch-Let-7-P2b4  Lgi-Let-7  Lhy-Let-7  Llo-Let-7  Loc-Let-7-P2b4  Mal-Let-7-P2b4a  Mal-Let-7-P2b4b  Mgi-Let-7  Mom-Let-7  Mun-Let-7-P2b4  Npo-Let-7  Oan-Let-7-P2b4  Obi-Let-7  Ofu-Let-7  Ovu-Let-7  Pau-Let-7  Pbv-Let-7-P2b4  Pca-Let-7  Pcr-Let-7  Pdu-Let-7  Pfl-Let-7  Ple-Let-7  Pmi-Let-7  Pve-Let-7  Rph-Let-7  Sko-Let-7  Sma-Let-7  Sne-Let-7  Snu-Let-7  Spt-Let-7-P2b4  Spu-Let-7  Sro-Let-7  Tca-Let-7  Tgu-Let-7-P2b4  Tni-Let-7-P2b4a  Tni-Let-7-P2b4b  Tur-Let-7  War-Let-7  Xbo-Let-7 
Node of Origin (locus) Clupeocephala
Node of Origin (family) Bilateria
Genome context
(danRer11)		 chr23: 5431216-5431292 [-] UCSC Ensembl
Clustered miRNAs
(< 50kb from Let-7-P2b4a)		 Let-7-P2b4a chr23: 5431216-5431292 [-] UCSC Ensembl
Let-7-P2a4a chr23: 5431431-5431503 [-] UCSC Ensembl
Precursor
(pre-Mir +30nt flank)
UAAGUACGUGUUUUUGGUGUCUGGACAAGGUGAGGUAGUAGGUUGUAUAGUUUGGUGGGAGGGAUCAAACCCUGUUCAGCUGAUAACUAUACAGUCUAUUGCCUUCCUUGUGUCACCUAAGGUCUGCCCGCUAAUGG
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Structure
        10        20          30        40        50        60        
UAAGUACGUGUUUUUGGUGUC-   -|     U          GU         UGGUGGGAGGGAUCA 
                      UGG ACAAGG GAGGUAGUAG  UGUAUAGUU               A
                      ACU UGUUCC UUCCGUUAUC  ACAUAUCAA               A
GGUAAUCGCCCGUCUGGAAUCC   G^     -          UG         UAGUCGACUUGUCCC 
     130       120       110        100        90        80        70
Deep sequencing
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CommentAlthough there is a templated T at the 3' end of the 3p arm, the post-transcriptional addition of a terminal 3' U is supported by the 3' DcRNA reads.
3' NTU Yes
MotifsCNNC at 3p(+17)
Tissue expression
-   +
Br Br Em Ey Gu Gu He Li Li Ov Te
Mature sequence

Dre-Let-7-P2b4a_5p
mirBase accessionMIMAT0001759
Sequence 
0- UGAGGUAGUAGGUUGUAUAGUU -22
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Proposed targets TargetScanFish: dre-let-7a
Star sequence

Dre-Let-7-P2b4a_3p*
mirBase accessionNone
Sequence 
56- CUAUACAGUCUAUUGCCUUCC -77
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