Mir-146-P4-v2

MirGeneDB ID

Dre-Mir-146-P4-v2

Family name

MIR-146 (all species)

Seed

UGAGAAC

Species

Zebrafish (Danio rerio)

MiRBase ID

dre-mir-146b

Paralogues

Dre-Mir-146-P1 Dre-Mir-146-P4-v1

Orthologues

Ami-Mir-146-P4 Bta-Mir-146-P4-v1 Bta-Mir-146-P4-v2 Cfa-Mir-146-P4 Cja-Mir-146-P4 Cli-Mir-146-P4 Cmi-Mir-146-P4 Cpi-Mir-146-P4 Cpo-Mir-146-P4 Dno-Mir-146-P4 Ebu-Mir-146 Eca-Mir-146-P4-v1 Eca-Mir-146-P4-v2 Gga-Mir-146-P4 Hsa-Mir-146-P4 Laf-Mir-146-P4 Lch-Mir-146-P4 Loc-Mir-146-P4 Mdo-Mir-146-P4 Mml-Mir-146-P4 Mmr-Mir-146-P4 Mmu-Mir-146-P4 Mun-Mir-146-P4 Neu-Mir-146-P4 Oan-Mir-146-P4 Ocu-Mir-146-P4 Pab-Mir-146-P4 Pma-Mir-146 Rno-Mir-146-P4 Sha-Mir-146-P4 Spt-Mir-146-P4 Sto-Mir-146-P4 Tgu-Mir-146-P4 Xla-Mir-146-P4 Xtr-Mir-146-P4

Node of Origin (locus)

Gnathostomata

Node of Origin (family)

Vertebrata

Genome context
(danRer11)

chr21: 41639989-41640049 [+] UCSC Ensembl

Clustered miRNAs
(< 50kb from Mir-146-P4-v2)

Mir-146-P4-v2 chr21: 41639989-41640049 [+] UCSC Ensembl
Mir-146-P4-v1 chr21: 41639990-41640048 [+] UCSC Ensembl

Precursor
(pre-Mir +30nt flank)

GCUUCUGGAUGUUACACUGAGCUCUUGGCUUUGAGAACUGAAUUCCAAGGGUGUCUGCUUUAUAUUCAGCCCACGGAGUUCAGUUCUUAAGUUUGGAUGCUCACGGCCGUCUGAACACACU

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Structure

        10         20         30        40        50        60
GCUUCUGGAUGUUACAC-     -|  UG    U              AA    GUCUGCU 
                  UGAGC UCU  GCUU GAGAACUGAAUUCC  GGGU       U
                  ACUCG AGG  UGAA UUCUUGACUUGAGG  CCCG       U
UCACACAAGUCUGCCGGC     U^  UU    -              CA    ACUUAUA 
 .       110       100        90         80        70

Deep sequencing

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Comment

Although the terminal "T" is templated the distribution of reads (in particular the 3' offset reads) indicate that this is likely a Group 2 miRNA.

3' NTU

Yes

Motifs

CNNC at 3p(+17)

Tissue expression

Br	Br	Em	Ey	Gu	Gu	He	Li	Li	Ov	Te

Mature sequence

Dre-Mir-146-P4-v2_5p

mirBase accession

MIMAT0001844

Sequence

0- UUGAGAACUGAAUUCCAAGGGUG -23

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Proposed targets

TargetScanFish: dre-miR-146b

Star sequence

Dre-Mir-146-P4-v2_3p*

mirBase accession

None

Sequence

40- CCACGGAGUUCAGUUCUUAAG -61

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