Mir-17-P2a

MirGeneDB ID

Hsa-Mir-17-P2a

Family name

MIR-17 (all species)

Seed

AAGGUGC

Species

Human (Homo sapiens)

MiRBase ID

hsa-mir-18a

Paralogues

Hsa-Mir-17-P1a Hsa-Mir-17-P1c Hsa-Mir-17-P1d Hsa-Mir-17-P2c Hsa-Mir-17-P4a Hsa-Mir-17-P4c Hsa-Mir-17-P4d

Orthologues

Aca-Mir-17-P2a Ami-Mir-17-P2a Bta-Mir-17-P2a Cfa-Mir-17-P2a Cja-Mir-17-P2a Cli-Mir-17-P2a Cmi-Mir-17-P2a Cpi-Mir-17-P2a Cpo-Mir-17-P2a Dno-Mir-17-P2a Dre-Mir-17-P2a1 Dre-Mir-17-P2a2 Eca-Mir-17-P2a Ete-Mir-17-P2a Gga-Mir-17-P2a Gja-Mir-17-P2a Gmo-Mir-17-P2a1 Gmo-Mir-17-P2a2 Laf-Mir-17-P2a Lch-Mir-17-P2a Loc-Mir-17-P2a Mal-Mir-17-P2a2a Mal-Mir-17-P2a2b Mdo-Mir-17-P2a Mml-Mir-17-P2a Mmr-Mir-17-P2a Mmu-Mir-17-P2a Mun-Mir-17-P2a Neu-Mir-17-P2a Oan-Mir-17-P2a Ocu-Mir-17-P2a Pab-Mir-17-P2a Pbv-Mir-17-P2a Rno-Mir-17-P2a Sha-Mir-17-P2a Spt-Mir-17-P2a Sto-Mir-17-P2a Tgu-Mir-17-P2a Tni-Mir-17-P2a1 Tni-Mir-17-P2a2 Xla-Mir-17-P2a3 Xla-Mir-17-P2a4 Xtr-Mir-17-P2a

Node of Origin (locus)

Gnathostomata

Node of Origin (family)

Vertebrata

Genome context
(hg38)

chr13: 91350756-91350820 [+] UCSC Ensembl

Clustered miRNAs
(< 50kb from Mir-17-P2a)

Mir-17-P1a chr13: 91350618-91350677 [+] UCSC Ensembl
Mir-17-P2a chr13: 91350756-91350820 [+] UCSC Ensembl
Mir-19-P1a chr13: 91350904-91350961 [+] UCSC Ensembl
Mir-17-P4a chr13: 91351072-91351130 [+] UCSC Ensembl
Mir-19-P2a chr13: 91351207-91351267 [+] UCSC Ensembl
Mir-92-P1a chr13: 91351324-91351382 [+] UCSC Ensembl

Precursor
(pre-Mir +30nt flank)

GGGCCUGCUGAUGUUGAGUGCUUUUUGUUCUAAGGUGCAUCUAGUGCAGAUAGUGAAGUAGAUUAGCAUCUACUGCCCUAAGUGCUCCUUCUGGCAUAAGAAGUUAUGUAUUCAUCCAAUAAUUC

Get precursor sequence

Structure

        10          20        30          40        50        60 
GGGCCUGCUGAUGUUGAGU--         U   --|  U   UC   U    A   UGAAGUA 
                     GCUUUUUGU CUA  AGG GCA  UAG GCAG UAG       G
                     UGAAGAAUA GGU  UCC CGU  AUC CGUC AUC       A
CUUAAUAACCUACUUAUGUAU         C   CU^  U   GA   C    -   UACGAUU 
   120       110       100        90        80         70

Deep sequencing

Go to detailed chart

Comment

There is a second Drosha cut -2 on the 3p arm.

3' NTU

Motifs

CNNC at 3p(+17)

Tissue expression

Dc	Dc	Dr	Dr	Xp	Xp	Bl	Br	Br	Ce	Ce	Co	Fo	He	Ki	Le	Li	Li	Lu	Pa	Pl	Pl	Sk	Sk	Sk	Sm	Sp	Sp	St	Te	Th	Ut

Mature sequence

Hsa-Mir-17-P2a_5p

mirBase accession

MIMAT0000072

Sequence

0- UAAGGUGCAUCUAGUGCAGAUAG -23

Get sequence

Proposed targets

microrna.org: MIMAT0000072
TargetScanVert: hsa-miR-18a-5p
TargetMiner: hsa-miR-18a-5p
miRDB: MIMAT0000072

Star sequence

Hsa-Mir-17-P2a_3p*

mirBase accession

MIMAT0002891

Sequence

41- ACUGCCCUAAGUGCUCCUUCUGGC -65

Get sequence

Proposed targets

microrna.org: MIMAT0002891
TargetScanVert: hsa-miR-18a-3p
TargetMiner: hsa-miR-18a-3p
miRDB: MIMAT0002891