10 20 30 40 50
ACAGAAGCAGUUAGUUC---| U UU CA UAA UGAAG
AG U CAGGC UGAUGUCCAACGCAUUCUUG G
UC G GUUCG ACUACAGGUUGUGUAAGAAC U
CUGUAAGGAAGACUACAUAU^ - GG UG - AC CGAAU
110 100 90 80 70 60
There is a second Drosha cut -1 on the 5p arm. The MIR-219 family shows substantial variation of arm-usage and is currently, across all species, considered a co-mature.